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2.A.1.1.8
Myoinositol:H+ symporter    

Accession Number:P30605
Protein Name:ITR1 aka YDR497C aka D9719.3
Length:584
Molecular Weight:63570.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

Genevestigator: P30605
eggNOG: fuNOG04593
HEGENOM: HBG744444
DIP: DIP-7406N
RefSeq: NP_010785.1   
Entrez Gene ID: 852108   
Pfam: PF00083   
KEGG: sce:YDR497C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0042802 F:identical protein binding
GO:0005365 F:myo-inositol transmembrane transporter acti...
GO:0015798 P:myo-inositol transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae.”  Nikawa J.et.al.   2040626
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[3] “A proteomics approach to understanding protein ubiquitination.”  Peng J.et.al.   12872131
[4] “A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.”  Hitchcock A.L.et.al.   14557538
[5] “Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.”  Gruhler A.et.al.   15665377
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGIHIPYLTS KTSQSNVGDA VGNADSVEFN SEHDSPSKRG KITLESHEIQ RAPASDDEDR 
61:	IQIKPVNDED DTSVMITFNQ SLSPFIITLT FVASISGFMF GYDTGYISSA LISIGTDLDH 
121:	KVLTYGEKEI VTAATSLGAL ITSIFAGTAA DIFGRKRCLM GSNLMFVIGA ILQVSAHTFW 
181:	QMAVGRLIMG FGVGIGSLIA PLFISEIAPK MIRGRLTVIN SLWLTGGQLV AYGCGAGLNY 
241:	VNNGWRILVG LSLIPTAVQF TCLCFLPDTP RYYVMKGDLA RATEVLKRSY TDTSEEIIER 
301:	KVEELVTLNQ SIPGKNVPEK VWNTIKELHT VPSNLRALII GCGLQAIQQF TGWNSLMYFS 
361:	GTIFETVGFK NSSAVSIIVS GTNFIFTLVA FFSIDKIGRR TILLIGLPGM TMALVVCSIA 
421:	FHFLGIKFDG AVAVVVSSGF SSWGIVIIVF IIVFAAFYAL GIGTVPWQQS ELFPQNVRGI 
481:	GTSYATATNW AGSLVIASTF LTMLQNITPA GTFAFFAGLS CLSTIFCYFC YPELSGLELE 
541:	EVQTILKDGF NIKASKALAK KRKQQVARVH ELKYEPTQEI IEDI