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2.A.1.1.80
Insulin-responsive facilitative glucose transporter in skeletal and cardiac muscle, adipose, and other tissues, Glut4 (GTR4; SLC2A4; 509aas). Defects in Glut4 cause noninsulin-dependent diabetes mellitus (NIDDM). Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor (Gonzalez et al., 2011). The first luminal loop confers insulin responsiveness to GLUT4 (Kim and Kandror, 2012). Exercise increases Glut4 synthesis in a process involving several protein kinases, the Glut4 enhancer factor (GEF; SLC2A4 regulator; Q9NR83), and the myocyte enhancing factor 2 (MEF2; NP_001139257). (McGee and Hargreaves 2006; Wright 2007; Zorzano et al. 2005)

Accession Number:P14672
Protein Name:Solute carrier family 2, facilitated glucose transporter member 4
Length:509
Molecular Weight:54787.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Endomembrane system1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: P14672 P14672
eggNOG: prNOG06425 COG0477
HEGENOM: HBG744444 HOG000202871
Entrez Gene ID: 6517   
Pfam: PF00083   
KEGG: hsa:6517    hsa:6517   

Gene Ontology

GO:0009897 C:external side of plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0048471 C:perinuclear region of cytoplasm
GO:0055056 F:D-glucose transmembrane transporter activity
GO:0005515 F:protein binding
GO:0005975 P:carbohydrate metabolic process
GO:0042593 P:glucose homeostasis
GO:0046323 P:glucose import
GO:0030136 C:clathrin-coated vesicle
GO:0005905 C:coated pit
GO:0030659 C:cytoplasmic vesicle membrane
GO:0070062 C:extracellular vesicular exosome
GO:0032593 C:insulin-responsive compartment
GO:0000299 C:integral to membrane of membrane fraction
GO:0005624 C:membrane fraction
GO:0005792 C:microsome
GO:0005771 C:multivesicular body
GO:0042383 C:sarcolemma
GO:0005625 C:soluble fraction
GO:0030140 C:trans-Golgi network transport vesicle
GO:0012506 C:vesicle membrane
GO:0005355 F:glucose transmembrane transporter activity
GO:0050873 P:brown fat cell differentiation
GO:0032869 P:cellular response to insulin stimulus
GO:0045471 P:response to ethanol
GO:0044281 P:small molecule metabolic process

References (23)

[1] “Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.”  Fukumoto H.et.al.   2656669
[2] “Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.”  Buse J.B.et.al.   1397719
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter.”  Chiaramonte R.et.al.   7916714
[5] “A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts.”  Verhey K.J.et.al.   8300557
[6] “The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.”  Lalioti V.S.et.al.   11842083
[7] “Identification and characterization of p49/STRAP as a novel GLUT4-binding protein.”  Lisinski I.et.al.   16647043
[8] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
[9] “Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.”  Kusari J.et.al.   1918382
[10] “Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects.”  Choi W.H.et.al.   1756912
[11] “Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population.”  O'Rahilly S.et.al.   1521731
[12] “Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.”  Fukumoto H.et.al.   2656669
[13] “Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.”  Buse J.B.et.al.   1397719
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter.”  Chiaramonte R.et.al.   7916714
[16] “A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts.”  Verhey K.J.et.al.   8300557
[17] “The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.”  Lalioti V.S.et.al.   11842083
[18] “Identification and characterization of p49/STRAP as a novel GLUT4-binding protein.”  Lisinski I.et.al.   16647043
[19] “Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.”  Jeyaraj S.et.al.   17382906
[20] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
[21] “Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.”  Kusari J.et.al.   1918382
[22] “Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects.”  Choi W.H.et.al.   1756912
[23] “Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population.”  O'Rahilly S.et.al.   1521731

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FASTA formatted sequence
1:	MPSGFQQIGS EDGEPPQQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK VIEQSYNETW 
61:	LGRQGPEGPS SIPPGTLTTL WALSVAIFSV GGMISSFLIG IISQWLGRKR AMLVNNVLAV 
121:	LGGSLMGLAN AAASYEMLIL GRFLIGAYSG LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI 
181:	VIGILIAQVL GLESLLGTAS LWPLLLGLTV LPALLQLVLL PFCPESPRYL YIIQNLEGPA 
241:	RKSLKRLTGW ADVSGVLAEL KDEKRKLERE RPLSLLQLLG SRTHRQPLII AVVLQLSQQL 
301:	SGINAVFYYS TSIFETAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR TLHLLGLAGM 
361:	CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG PIPWFIVAEL FSQGPRPAAM 
421:	AVAGFSNWTS NFIIGMGFQY VAEAMGPYVF LLFAVLLLGF FIFTFLRVPE TRGRTFDQIS 
481:	AAFHRTPSLL EQEVKPSTEL EYLGPDEND