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2.A.1.1.87
solute carrier family 2, member 12, Glut12 of 617 aas and 12 TMSs.  In contrast to most mammalian members of this family, this protein has been reported to be a glucose:proton symporter (Wilson-O'Brien et al. 2010).

Accession Number:Q8TD20
Protein Name:Solute carrier family 2, facilitated glucose transporter member 12
Length:617
Molecular Weight:66966.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Endomembrane system1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: Q8TD20 Q8TD20
eggNOG: COG0477 COG0477
HEGENOM: HOG000202868 HOG000202868
Entrez Gene ID: 154091   
Pfam: PF00083   
KEGG: hsa:154091    hsa:154091   

Gene Ontology

GO:0012505 C:endomembrane system
GO:0016021 C:integral to membrane
GO:0048471 C:perinuclear region of cytoplasm
GO:0005886 C:plasma membrane
GO:0022891 F:substrate-specific transmembrane transporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (8)

[1] “Identification of a novel glucose transporter-like protein -- GLUT-12.”  Rogers S.et.al.   11832379
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Identification of a novel glucose transporter-like protein -- GLUT-12.”  Rogers S.et.al.   11832379
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVPVENTEGP SLLNQKGTAV ETEGSGSRHP PWARGCGMFT FLSSVTAAVS GLLVGYELGI 
61:	ISGALLQIKT LLALSCHEQE MVVSSLVIGA LLASLTGGVL IDRYGRRTAI ILSSCLLGLG 
121:	SLVLILSLSY TVLIVGRIAI GVSISLSSIA TCVYIAEIAP QHRRGLLVSL NELMIVIGIL 
181:	SAYISNYAFA NVFHGWKYMF GLVIPLGVLQ AIAMYFLPPS PRFLVMKGQE GAASKVLGRL 
241:	RALSDTTEEL TVIKSSLKDE YQYSFWDLFR SKDNMRTRIM IGLTLVFFVQ ITGQPNILFY 
301:	ASTVLKSVGF QSNEAASLAS TGVGVVKVIS TIPATLLVDH VGSKTFLCIG SSVMAASLVT 
361:	MGIVNLNIHM NFTHICRSHN SINQSLDESV IYGPGNLSTN NNTLRDHFKG ISSHSRSSLM 
421:	PLRNDVDKRG ETTSASLLNA GLSHTEYQIV TDPGDVPAFL KWLSLASLLV YVAAFSIGLG 
481:	PMPWLVLSEI FPGGIRGRAM ALTSSMNWGI NLLISLTFLT VTDLIGLPWV CFIYTIMSLA 
541:	SLLFVVMFIP ETKGCSLEQI SMELAKVNYV KNNICFMSHH QEELVPKQPQ KRKPQEQLLE 
601:	CNKLCGRGQS RQLSPET