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2.A.1.1.89
Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1)

Accession Number:Q9NY64
Protein Name:Solute carrier family 2, facilitated glucose transporter member 8
Length:477
Molecular Weight:50819.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: Q9NY64
eggNOG: COG0477
HEGENOM: HOG000202868
Entrez Gene ID: 29988   
Pfam: PF00083   
KEGG: hsa:29988   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0005887 C:integral to plasma membrane
GO:0043231 C:intracellular membrane-bounded organelle
GO:0008021 C:synaptic vesicle
GO:0005536 F:glucose binding
GO:0005355 F:glucose transmembrane transporter activity
GO:0005975 P:carbohydrate metabolic process
GO:0008286 P:insulin receptor signaling pathway
GO:0007141 P:male meiosis I
GO:0001666 P:response to hypoxia

References (4)

[1] “GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity.”  Doege H.et.al.   10821868
[2] “GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues.”  Ibberson M.R.et.al.   10671487
[3] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTPEDPEETQ PLLGPPGGSA PRGRRVFLAA FAAALGPLSF GFALGYSSPA IPSLQRAAPP 
61:	APRLDDAAAS WFGAVVTLGA AAGGVLGGWL VDRAGRKLSL LLCSVPFVAG FAVITAAQDV 
121:	WMLLGGRLLT GLACGVASLV APVYISEIAY PAVRGLLGSC VQLMVVVGIL LAYLAGWVLE 
181:	WRWLAVLGCV PPSLMLLLMC FMPETPRFLL TQHRRQEAMA ALRFLWGSEQ GWEDPPIGAE 
241:	QSFHLALLRQ PGIYKPFIIG VSLMAFQQLS GVNAVMFYAE TIFEEAKFKD SSLASVVVGV 
301:	IQVLFTAVAA LIMDRAGRRL LLVLSGVVMV FSTSAFGAYF KLTQGGPGNS SHVAISAPVS 
361:	AQPVDASVGL AWLAVGSMCL FIAGFAVGWG PIPWLLMSEI FPLHVKGVAT GICVLTNWLM 
421:	AFLVTKEFSS LMEVLRPYGA FWLASAFCIF SVLFTLFCVP ETKGKTLEQI TAHFEGR