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2.A.1.1.9
Lactose, galactose:H+ symporter

Accession Number:P07921
Protein Name:LacP aka LAC12
Length:587
Molecular Weight:65383.00
Species:Kluyveromyces lactis (Yeast) [28985]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Lactose, Galactose, H+

Cross database links:

eggNOG: fuNOG06424
HEGENOM: HBG626205
RefSeq: XP_452193.1   
Entrez Gene ID: 2897085   
Pfam: PF00083   
KEGG: kla:KLLA0B14861   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022891 F:substrate-specific transmembrane transporte...
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Primary structure of the lactose permease gene from the yeast Kluyveromyces lactis. Presence of an unusual transcript structure.”  Chang Y.-D.et.al.   3053697
[2] “Genome evolution in yeasts.”  Dujon B.et.al.   15229592

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MADHSSSSSS LQKKPINTIE HKDTLGNDRD HKEALNSDND NTSGLKINGV PIEDAREEVL 
61:	LPGYLSKQYY KLYGLCFITY LCATMQGYDG ALMGSIYTED AYLKYYHLDI NSSSGTGLVF 
121:	SIFNVGQICG AFFVPLMDWK GRKPAILIGC LGVVIGAIIS SLTTTKSALI GGRWFVAFFA 
181:	TIANAAAPTY CAEVAPAHLR GKVAGLYNTL WSVGSIVAAF STYGTNKNFP NSSKAFKIPL 
241:	YLQMMFPGLV CIFGWLIPES PRWLVGVGRE EEAREFIIKY HLNGDRTHPL LDMEMAEIIE 
301:	SFHGTDLSNP LEMLDVRSLF RTRSDRYRAM LVILMAWFGQ FSGNNVCSYY LPTMLRNVGM 
361:	KSVSLNVLMN GVYSIVTWIS SICGAFFIDK IGRREGFLGS ISGAALALTG LSICTARYEK 
421:	TKKKSASNGA LVFIYLFGGI FSFAFTPMQS MYSTEVSTNL TRSKAQLLNF VVSGVAQFVN 
481:	QFATPKAMKN IKYWFYVFYV FFDIFEFIVI YFFFVETKGR SLEELEVVFE APNPRKASVD 
541:	QAFLAQVRAT LVQRNDVRVA NAQNLKEQEP LKSDADHVEK LSEAESV