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2.A.1.1.99
Facilitated trehalose transporter Tret1-1 (DmTret1-1); transports trehalose with a Km of 11 mM (Kanamori et al. 2010).  Tret1 orthologs of other insects examined have differing Km values (Apis mellifera, 9 mM; Anopheles gambiae, 46 mM, and Bombyx mori, 72 mM).

Accession Number:A1Z8N1
Protein Name:Facilitated trehalose transporter Tret1-1
Length:857
Molecular Weight:95188.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Trehalose

Cross database links:

eggNOG: COG0477
Entrez Gene ID: 36248   
Pfam: PF00083   
KEGG: dme:Dmel_CG3003   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0044459 C:plasma membrane part
GO:0015574 F:trehalose transmembrane transporter activity

References (4)

[1] “The trehalose transporter 1 gene sequence is conserved in insects and encodes proteins with different kinetic properties involved in trehalose import into peripheral tissues.”  Kanamori Y.et.al.   20035867
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “Phosphoproteome analysis of Drosophila melanogaster embryos.”  Zhai B.et.al.   18327897

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSGRDNRGAG GGGGGHQPLS NAMGKLKEKL TRVGDELGYH RVESNLSTSN TATSLDTILP 
61:	EDPFLFPQVS PQRHPQNTVR TQRLLEDEPP LSFRPLLEDD DINEPPTQQQ QRTPLRASGS 
121:	LELTPLPPPP TSLEIREHRD RQQRGAQGDE LQRSKQSLKG SRVSFERRDT GNSNTNSNKA 
181:	AESSDEDSFE EKRTGFQQQK ATSVDHKGIL KDLKHILAND NRRQFQAKKH VSLDVKGTRF 
241:	LQDLLKESSS EEEFHKTRRE FQGRKHQSLD PRVTFKLDKV LQGSSTDSDE EGEDAEHKRL 
301:	IHRPKDITKP VIIDLKDLES ESDEDFLTSR QHFQQQRSIS TDSRKSRRLY EMDEMDNKRG 
361:	ENIRHAVPFV RQITEDGKPK LEVYRPTTNP IYIWTQVLAA LSVSLGSLVV GFVSAYTSPA 
421:	LVSMTDRNIT SFEVTQDAGS WVGGIMPLAG LAGGIAGGPL IEYLGRRNTI LATAVPFIVS 
481:	SLLIACAVNV AMVLCGRFLA GFCVGIASLS LPVYLGETVQ PEVRGTLGLL PTAFGNIGIL 
541:	LCFVAGSFMN WSMLAFLGAA LPVPFLILMF LIPETPRWFV GRGLEERARK ALKWLRGKEA 
601:	DVEPELKGLM RSQADADRQA SRNTMLELLK LNNLKPLSIS LGLMFFQQFS GINAVIFYTV 
661:	QIFKDAGSTI DGNLCTIIVG IVNFLATFIG IVLIDRAGRK ILLYVSDIAM VLTLFVLGGF 
721:	FYCKTYGPDV SHLGWLPLTC FVIYILGFSL GFGPIPWLMM GEILPAKIRG SAASVATAFN 
781:	WFCTFVVTKT FQDLTVAMGA HGAFWLFGAI CFVGLFFVII YVPETQGKTL EDIERKMMGR 
841:	VRRMSSVANI KPLSFNM