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2.A.1.11.3
Inner membrane protein yhjX (possibly a pyruvate exporter) (Vilhena et al. 2017).  Regulated by Crp as well as the LytS-like histidine sensor kinase, BtsS or YehU, and the corresponding LytTR-like response regulator, BtsR or YehT (Kristoficova et al. 2017).  Possibly induced by peptides as cells enter the stationary growth phase because they release extracellular pyruvate, the true inducer (Kristoficova et al. 2017).  Forms a complex with the BtsT (CsiA; YjiY) transporter (TC# 2.A.114.1.9) and two sensor kinase/response regulator pairs, BtsS/BtsR (YehU/YehT) and YdpA/YdpB, both of which respond to extracellular pyruvate, but with differing affinities (Behr et al. 2014).  The carbon storage regulator A (CsrA) is involved in posttranscriptional regulation of both BtsT (YjiY) and YjiX, a 67 aa soluble protein of unknown function (Behr et al. 2014).

Accession Number:P37662
Protein Name:Inner membrane protein yhjX
Length:402
Molecular Weight:42951.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Unknown, Oxalate

Cross database links:

Genevestigator: P37662
EchoBASE: EB2177
EcoGene: EG12268
eggNOG: COG0477
HEGENOM: HOG000058263
DIP: DIP-12395N
Entrez Gene ID: 948066   
Pfam: PF07690   
KEGG: eco:b3547   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (4)

[1] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTPSNYQRTR WLTLIGTIIT QFALGSVYTW SLFNGALSAK LDAPVSQVAF SFGLLSLGLA 
61:	ISSSVAGKLQ ERFGVKRVTM ASGILLGLGF FLTAHSDNLM MLWLSAGVLV GLADGAGYLL 
121:	TLSNCVKWFP ERKGLISAFA IGSYGLGSLG FKFIDTQLLE TVGLEKTFVI WGAIALLMIV 
181:	FGATLMKDAP KQEVKTSNGV VEKDYTLAES MRKPQYWMLA VMFLTACMSG LYVIGVAKDI 
241:	AQSLAHLDVV SAANAVTVIS IANLSGRLVL GILSDKIARI RVITIGQVIS LVGMAALLFA 
301:	PLNAVTFFAA IACVAFNFGG TITVFPSLVS EFFGLNNLAK NYGVIYLGFG IGSICGSIIA 
361:	SLFGGFYVTF YVIFALLILS LALSTTIRQP EQKMLREAHG SL