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2.A.1.12.2
The lactate/pyruvate:H+ symporter. Residues in the substrate translocation pathway have been reported (Soares-Silva et al., 2011).

Accession Number:P36035
Protein Name:Jen1 aka YKL217w
Length:616
Molecular Weight:69376.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Lactate, pyruvate, H+

Cross database links:

Genevestigator: P36035
eggNOG: fuNOG06522
HEGENOM: HBG293363
DIP: DIP-8064N
RefSeq: NP_012705.1   
Entrez Gene ID: 853663   
Pfam: PF00083   
KEGG: sce:YKL217W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0005886 C:plasma membrane
GO:0015144 F:carbohydrate transmembrane transporter acti...
GO:0015129 F:lactate transmembrane transporter activity
GO:0015727 P:lactate transport

References (5)

[1] “The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein.”  Tzermia M.et.al.   7941750
[2] “Complete DNA sequence of yeast chromosome XI.”  Dujon B.et.al.   8196765
[3] “A proteomics approach to understanding protein ubiquitination.”  Peng J.et.al.   12872131
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[5] “Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.”  Reinders J.et.al.   17761666

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSSITDEKI SGEQQQPAGR KLYYNTSTFA EPPLVDGEGN PINYEPEVYN PDHEKLYHNP 
61:	SLPAQSIQDT RDDELLERVY SQDQGVEYEE DEEDKPNLSA ASIKSYALTR FTSLLHIHEF 
121:	SWENVNPIPE LRKMTWQNWN YFFMGYFAWL SAAWAFFCVS VSVAPLAELY DRPTKDITWG 
181:	LGLVLFVRSA GAVIFGLWTD KSSRKWPYIT CLFLFVIAQL CTPWCDTYEK FLGVRWITGI 
241:	AMGGIYGCAS ATAIEDAPVK ARSFLSGLFF SAYAMGFIFA IIFYRAFGYF RDDGWKILFW 
301:	FSIFLPILLI FWRLLWPETK YFTKVLKARK LILSDAVKAN GGEPLPKANF KQKMVSMKRT 
361:	VQKYWLLFAY LVVLLVGPNY LTHASQDLLP TMLRAQLGLS KDAVTVIVVV TNIGAICGGM 
421:	IFGQFMEVTG RRLGLLIACT MGGCFTYPAF MLRSEKAILG AGFMLYFCVF GVWGILPIHL 
481:	AELAPADARA LVAGLSYQLG NLASAAASTI ETQLADRYPL ERDASGAVIK EDYAKVMAIL 
541:	TGSVFIFTFA CVFVGHEKFH RDLSSPVMKK YINQVEEYEA DGLSISDIVE QKTECASVKM 
601:	IDSNVSKTYE EHIETV