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2.A.1.13.11
Solute carrier family 16, member 5 (monocarboxylic acid transporter 6) of 505 aas and 12 TMSs. Found on the luminal side of small intestinal epithelial cells (Kohyama et al. 2013). MCT6 mediates uptake of nateglinide, an oral hypoglycemic agent. The K(t) for nateglinide is 46 μM. Thus, MCT6 may play a role in the intestinal absorption of nateglinide, although other transporters are also likely to be involved (Kohyama et al. 2013).

Accession Number:O15375
Protein Name:Monocarboxylate transporter 6
Length:505
Molecular Weight:54994.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Monocarboxylates

Cross database links:

Genevestigator: O15375 O15375
eggNOG: NOG264865 NOG264865
HEGENOM: HOG000280688 HOG000280688
Entrez Gene ID: 9121   
Pfam: PF07690   
Drugbank: Drugbank Link   
KEGG: hsa:9121    hsa:9121   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015355 F:secondary active monocarboxylate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0015711 P:organic anion transport
GO:0008028 F:monocarboxylic acid transmembrane transporter activity

References (4)

[1] “Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.”  Price N.T.et.al.   9425115
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.”  Price N.T.et.al.   9425115
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPQALERADG SWAWVVLLAT MVTQGLTLGF PTCIGIFFTE LQWEFQASNS ETSWFPSILT 
61:	AVLHMAGPLC SILVGRFGCR VTVMLGGVLA SLGMVASSFS HNLSQLYFTA GFITGLGMCF 
121:	SFQSSITVLG FYFVRRRVLA NALASMGVSL GITLWPLLSR YLLENLGWRG TFLVFGGIFL 
181:	HCCICGAIIR PVATSVAPET KECPPPPPET PALGCLAACG RTIQRHLAFD ILRHNTGYCV 
241:	YILGVMWSVL GFPLPQVFLV PYAMWHSVDE QQAALLISII GFSNIFLRPL AGLMAGRPAF 
301:	ASHRKYLFSL ALLLNGLTNL VCAASGDFWV LVGYCLAYSV SMSGIGALIF QVLMDIVPMD 
361:	QFPRALGLFT VLDGLAFLIS PPLAGLLLDA TNNFSYVFYM SSFFLISAAL FMGGSFYALQ 
421:	KKEQGKQAVA ADALERDLFL EAKDGPGKQR SPEIMCQSSR QPRPAGVNKH LWGCPASSRT 
481:	SHEWLLWPKA VLQAKQTALG WNSPT