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2.A.1.13.12
Solute carrier family 16, member 14 (monocarboxylic acid transporter 14), ATBo or MCT14.  Transports carnitine with low affinity (~ 1 mM) (Ingoglia et al. 2015). Its tissue localization in the mouse has been determined (Roshanbin et al. 2016).  

Accession Number:Q7RTX9
Protein Name:Monocarboxylate transporter 14
Length:510
Molecular Weight:56254.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Monocarboxylates, Carnitine

Cross database links:

Genevestigator: Q7RTX9 Q7RTX9
eggNOG: COG0477 COG0477
HEGENOM: HOG000013205 HOG000013205
Entrez Gene ID: 151473   
Pfam: PF07690   
KEGG: hsa:151473    hsa:151473   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity

References (8)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.”  Halestrap A.P.et.al.   12739169
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.”  Halestrap A.P.et.al.   12739169

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS QMALGVLNVE 
61:	WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR QTAIIGGLVN SLGWVLSAYA 
121:	ANVHYLFITF GVAAGLGSGM AYLPAVVMVG RYFQKRRALA QGLSTTGTGF GTFLMTVLLK 
181:	YLCAEYGWRN AMLIQGAVSL NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST 
241:	GQQGRTEEKD GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW 
301:	YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN DVFPLTSIIA 
361:	IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP LMHTYAGLAV ICALIGFSSG 
421:	YFSLMPVVTE DLVGIEHLAN AYGIIICANG ISALLGPPFA GWIYDITQKY DFSFYICGLL 
481:	YMIGILFLLI QPCIRIIEQS RRKYMDGAHV