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2.A.1.13.14
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)

Accession Number:Q6ZSM3
Protein Name:Monocarboxylate transporter 12
Length:486
Molecular Weight:53075.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Monocarboxylates

Cross database links:

Genevestigator: Q6ZSM3 Q6ZSM3
eggNOG: COG0477 COG0477
HEGENOM: HOG000280688 HOG000280688
Entrez Gene ID: 387700   
Pfam: PF07690   
KEGG: hsa:387700    hsa:387700   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity

References (8)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria.”  Kloeckener-Gruissem B.et.al.   18304496
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria.”  Kloeckener-Gruissem B.et.al.   18304496

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKVNRARST SPPDGGWGWM IVAGCFLVTI CTRAVTRCIS IFFVEFQTYF TQDYAQTAWI 
61:	HSIVDCVTML CAPLGSVVSN HLSCQVGIML GGLLASTGLI LSSFATSLKH LYLTLGVLTG 
121:	LGFALCYSPA IAMVGKYFSR RKALAYGIAM SGSGIGTFIL APVVQLLIEQ FSWRGALLIL 
181:	GGFVLNLCVC GALMRPITLK EDHTTPEQNH VCRTQKEDIK RVSPYSSLTK EWAQTCLCCC 
241:	LQQEYSFLLM SDFVVLAVSV LFMAYGCSPL FVYLVPYALS VGVSHQQAAF LMSILGVIDI 
301:	IGNITFGWLT DRRCLKNYQY VCYLFAVGMD GLCYLCLPML QSLPLLVPFS CTFGYFDGAY 
361:	VTLIPVVTTE IVGTTSLSSA LGVVYFLHAV PYLVSPPIAG RLVDTTGSYT AAFLLCGFSM 
421:	IFSSVLLGFA RLIKRMRKTQ LQFIAKESDP KLQLWTNGSV AYSVARELDQ KHGEPVATAV 
481:	PGYSLT