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2.A.1.13.2
The low affinity aromatic amino acid (Tyr, Trp, Phe) transporter, TAT1 (T-type amino acid transporter), MCT10, Slc16a10.  Also transports N-methyl amino acids and thyroid hormones.  Essential for aromatic amino acid homeostasis in various tissues of mice (Mariotta et al. 2012). MCT10 is 58% identical to MCT8. Both transporters mediate T3 transport, but while MCT8 also transports rT3 and T4, these compounds are not efficiently transported by MCT10.  A few amino acyl residue substitutions in the human orthologue broadens the substrate specificity of this porter (Johannes et al. 2016).

Accession Number:Q91Y77
Protein Name:Tat1
Length:514
Molecular Weight:55663.00
Species:Rattus norvegicus [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate tyrosine, tryptophan, phenylalanine

Cross database links:

Genevestigator: Q91Y77
eggNOG: roNOG12562
RefSeq: NP_620186.1   
Entrez Gene ID: 170566   
Pfam: PF07690   
KEGG: rno:170566   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0055085 P:transmembrane transport

References (1)

[1] “Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.”  Kim D.K.et.al.   11278508

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVPSLEEPAA AERETNEAQP PGPAPSDDAP LPVPGPSDVS DGSVEKVEVE LTRSTGNQEP 
61:	PEPPEGGWGW LVMLAAMWCN GSVFGIQNAY GVLFVSMLET FGAKDDDNMA FKAAWVGSLS 
121:	MGMIFFCCPI VSVFTDMFGC RRTAVLGAAV GFVGLMSSSF VSSIEPLYFT YGVVFACGCS 
181:	FAYQPSLVIL GHYFKKRLGL VNGIVTAGSS VFTILLPLLL GNLTSTVGLC YTLRILCIFM 
241:	FVLFLAGFTY RPLVPSSKEK ESEDSRSSFF SRRKLSPPKK IFNFALFKET AYAVWAAGIP 
301:	LALFGYFVPY VHLMNHVKER FKDVNNKEVL FMCIGVTSGV GRLLFGRIAD YLPGVKKVYL 
361:	QVLSFFFIGL TSMMIPLCSV FGALIALCLI MGLFDGCFIS IMAPIAFELV GPQDASQAIG 
421:	FLLGFMSIPM TVGPPVAGLL HDKLGSYDLA FYLAGIPPFI GGAVLCLIPW IHSKKQREIS 
481:	KNTGGEKMEK MLANQSSLLS SSSGIFKKES DSII