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2.A.1.13.5
Low affinity monocarboxylate transporter-2 (MCT2). Transports γ-hydroxybutyrate (Wang and Morris, 2007). MCT2 requires the ancillary protein, embigin (Q6PCB8; 8.A.23.1.2) for plasma membrane localization (Ovens et al., 2010). It is present in neurons but not astrocytes where the low affinity MCT1 and MCT4 predominate (Hertz and Dienel 2013). Partially localizes to the peroxysomal membrane (Visser et al. 2007). MCT1 is a negative regulator and MCT2 a positive regulator of osteoclast differentiation, while MCT2 is required for bone resorption by osteoclasts (Imai et al. 2019).

Accession Number:O60669
Protein Name:MCT2
Length:478
Molecular Weight:52186.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Monocarboxylates, Gamma-hydroxybutyrate

Cross database links:

Genevestigator: O60669 O60669
eggNOG: prNOG07604 COG0477
HEGENOM: HBG444740 HOG000280688
Entrez Gene ID: 9194   
Pfam: PF07690   
Drugbank: Drugbank Link   
OMIM: 603654  gene
KEGG: hsa:9194   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005477 F:pyruvate secondary active transmembrane tra...
GO:0015355 F:secondary active monocarboxylate transmembr...
GO:0015293 F:symporter activity
GO:0006848 P:pyruvate transport
GO:0055085 P:transmembrane transport
GO:0005477 F:pyruvate secondary active transmembrane transporter activity
GO:0015355 F:secondary active monocarboxylate transmembrane transporter activity

References (3)

[1] “Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter.”  Lin R.-Y.et.al.   9786900
[2] “Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter.”  Lin R.-Y.et.al.   9786900
[3] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
Structure:
7BP3     

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI FHTTYSEIAW 
61:	ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM VLASFSSSVV QLYLTMGFIT 
121:	GLGLAFNLQP ALTIIGKYFY RKRPMANGLA MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI 
181:	LGSLLLNACV AGSLMRPLGP NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS 
241:	LFKHRGFLIY LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV 
301:	GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG FGSVSSVLFE 
361:	TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT GEYKYMYMSC GAIVVAASVW 
421:	LLIGNAINYR LLAKERKEEN ARQKSRESEP LSKSKHSEDV NVKVSNAQSV TSERETNI