TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.13.5
Monocarboxylate transporter-2 (MCT2). Transports γ-hydroxybutyrate (Wang and Morris, 2007). MCT2 requires the ancillary protein, embigin (Q6PCB8; 8.A.23.1.2) for plasma membrane localization (Ovens et al., 2010).  Partially localizes to the peroxysomal membrane (Visser et al. 2007).

Accession Number:O60669
Protein Name:MCT2
Length:478
Molecular Weight:52186.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Monocarboxylates, Gamma-hydroxybutyrate

Cross database links:

Genevestigator: O60669 O60669
eggNOG: prNOG07604 COG0477
HEGENOM: HBG444740 HOG000280688
Entrez Gene ID: 9194   
Pfam: PF07690   
Drugbank: Drugbank Link   
OMIM: 603654  gene
KEGG: hsa:9194   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005477 F:pyruvate secondary active transmembrane tra...
GO:0015355 F:secondary active monocarboxylate transmembr...
GO:0015293 F:symporter activity
GO:0006848 P:pyruvate transport
GO:0055085 P:transmembrane transport
GO:0005477 F:pyruvate secondary active transmembrane transporter activity
GO:0015355 F:secondary active monocarboxylate transmembrane transporter activity

References (3)

[1] “Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter.”  Lin R.-Y.et.al.   9786900
[2] “Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter.”  Lin R.-Y.et.al.   9786900
[3] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI FHTTYSEIAW 
61:	ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM VLASFSSSVV QLYLTMGFIT 
121:	GLGLAFNLQP ALTIIGKYFY RKRPMANGLA MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI 
181:	LGSLLLNACV AGSLMRPLGP NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS 
241:	LFKHRGFLIY LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV 
301:	GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG FGSVSSVLFE 
361:	TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT GEYKYMYMSC GAIVVAASVW 
421:	LLIGNAINYR LLAKERKEEN ARQKSRESEP LSKSKHSEDV NVKVSNAQSV TSERETNI