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2.A.1.13.8
Monocarboxylate transporter, MCT10. Transports thyroid horomones (Visser et al., 2010). Primary and secondary thyroid hormone transporters have been reviewed (Kinne et al., 2011).

Accession Number:Q8TF71
Protein Name:Monocarboxylate transporter 10
Length:515
Molecular Weight:55493.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Thyroid hormones

Cross database links:

COG0477
Genevestigator: Q8TF71 Q8TF71
HEGENOM: HBG717340 HOG000046644
Entrez Gene ID: 117247   
Pfam: PF07690   
KEGG: hsa:117247    hsa:117247   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0015801 P:aromatic amino acid transport
GO:0055085 P:transmembrane transport
GO:0006811 P:ion transport

References (10)

[1] “The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.”  Kim D.K.et.al.   11827462
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[6] “The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.”  Kim D.K.et.al.   11827462
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVLSQEEPDS ARGTSEAQPL GPAPTGAAPP PGPGPSDSPE AAVEKVEVEL AGPATAEPHE 
61:	PPEPPEGGWG WLVMLAAMWC NGSVFGIQNA CGVLFVSMLE TFGSKDDDKM VFKTAWVGSL 
121:	SMGMIFFCCP IVSVFTDLFG CRKTAVVGAA VGFVGLMSSS FVSSIEPLYL TYGIIFACGC 
181:	SFAYQPSLVI LGHYFKKRLG LVNGIVTAGS SVFTILLPLL LRVLIDSVGL FYTLRVLCIF 
241:	MFVLFLAGFT YRPLATSTKD KESGGSGSSL FSRKKFSPPK KIFNFAIFKV TAYAVWAVGI 
301:	PLALFGYFVP YVHLMKHVNE RFQDEKNKEV VLMCIGVTSG VGRLLFGRIA DYVPGVKKVY 
361:	LQVLSFFFIG LMSMMIPLCS IFGALIAVCL IMGLFDGCFI SIMAPIAFEL VGAQDVSQAI 
421:	GFLLGFMSIP MTVGPPIAGL LRDKLGSYDV AFYLAGVPPL IGGAVLCFIP WIHSKKQREI 
481:	SKTTGKEKME KMLENQNSLL SSSSGMFKKE SDSII