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2.A.1.13.9
Short chain monocarboxylate (lactate) transporter 3, MCT3. MCT1, 3 and 4 require the ancillary protein, basigin (P35613; 8.A.23.1.1) for plasma membrane localization (Ovens et al., 2010).

Accession Number:O95907
Protein Name:Monocarboxylate transporter 3
Length:504
Molecular Weight:52319.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Lactate

Cross database links:

Genevestigator: O95907 O95907
eggNOG: prNOG11428 NOG297999
HEGENOM: HBG444740 HOG000280688
Entrez Gene ID: 23539   
Pfam: PF07690   
Drugbank: Drugbank Link   
KEGG: hsa:23539    hsa:23539   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015129 F:lactate transmembrane transporter activity
GO:0015355 F:secondary active monocarboxylate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0007596 P:blood coagulation
GO:0050900 P:leukocyte migration
GO:0006090 P:pyruvate metabolic process
GO:0009925 C:basal plasma membrane

References (4)

[1] “Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2.”  Yoon H.et.al.   10493836
[2] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[3] “Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2.”  Yoon H.et.al.   10493836
[4] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF DAGYSDTAWV 
61:	SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI LASFATRLLE LYLTAGVLTG 
121:	LGLALNFQPS LIMLGLYFER RRPLANGLAA AGSPVFLSAL SPLGQQLLER FGWRGGFLLL 
181:	GGLLLHCCAC GAVMRPPPGP GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR 
241:	RLLDLAVCTD RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI 
301:	VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC VAFGLSYGMV 
361:	GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG RLVDVLKNYE IIFYLAGSEV 
421:	ALAGVFMAVA TNCCLRCAKA APSGPGTEGG ASDTEDAEAE GDSEPLPVVA EEPGNLEALE 
481:	VLSARGEPTE PEIEARPRLA AESV