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2.A.1.14.15
Apical membrane renal proximal tubule. Voltage-driven but Na+-independent organic anion transporter, OATv1 (transports p-aminohippurate; probably transports organic anions but not cations and not inorganic phosphate. It may catalyze excretion of various drugs, xenobiotics, and their metabolites) (Jutabha et al., 2003)

Accession Number:Q7YQJ7
Protein Name:Organic anion transporter OATv1
Length:467
Molecular Weight:52070.00
Species:Sus scrofa (Pig) [9823]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate p-aminohippurate, drugs, xenobiotics

Cross database links:

RefSeq: NP_999509.1   
Entrez Gene ID: 397621   
Pfam: PF07690   
KEGG: ssc:397621   

Gene Ontology

GO:0055085 P:transmembrane transport

References (1)

[1] “Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule.”  Jutabha P.et.al.   12740363

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLMDNQVPPK KVPKFCSVRY GIAILLLFCN VVVMSQRVCI SLTMIAMVNS TEPHGLSNIS 
61:	TKELQDNIKN PVYNWSPEIQ GIILSSIFYG VLISQIPAGY LSGIYSLKKM IGFALFFSSL 
121:	FTLLIPPVAE LGETLVIVCR IIKGLFQGVT LTAQQIIWTK WAPPLEQGRL TSLSLSGLLL 
181:	GPCVVMLMTG FICDSLGWPM VFYIFGAMGC VLSLLWFILY YEYPKDHPFI SIGEKEYITS 
241:	SLDQQDSSNS PSLPIKAMIK SPPLWVISLT NFAFFWTNSI LSMYTPMFIN FRFQINIREN 
301:	GLLSSLPHLF AWIFAVLAGH MADVFLSKNI LSLLTIRKLF TSLGLLLPAI FCLSLLYLSS 
361:	SFHATMIFLT LANATGSFTM GGLLINVLDI APRYYGFLKG VTNVIGLTGG LVSSTLTGMM 
421:	LSQDSESSWF KIFFLMSAIN VISQILYIIF AKAEVQDWAK ERQNTYL