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2.A.1.14.17
Pantothenate:H+ symporter, Liz1 (mutants cause abnormal mitosis due to a defect in ribonucleotide reductase) (Stolz et al., 2004)

Accession Number:O43000
Protein Name:Pantothenate transporter liz1
Length:514
Molecular Weight:57964.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate H+, Pantothenate

Cross database links:

eggNOG: fuNOG05390
HEGENOM: HBG324666
RefSeq: NP_596430.1   
Entrez Gene ID: 2540342   
Pfam: PF07690   
KEGG: spo:SPBC2G2.01c   

Gene Ontology

GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015233 F:pantothenate transporter activity
GO:0006633 P:fatty acid biosynthetic process
GO:0015887 P:pantothenate transmembrane transport

References (3)

[1] “Liz1p, a novel fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited.”  Moynihan E.B.et.al.   9950674
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[3] “Cell division defects of Schizosaccharomyces pombe liz1- mutants are caused by defects in pantothenate uptake.”  Stolz J.et.al.   15075270

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MALLNRLAKT FSPYYGLNKV EQKLLIKIDW FILSYCCVSY FINYLDRSSI NNAYLSGMQE 
61:	DLKMHGNELQ DINVVFTCGY IIGQLPGSYA LQRVPARLWF SVMNILWGLM TIFSFAVHSV 
121:	RALMILRFFM AVAEASTFAG THYILGAWYK ESELCKRAGI FSASGLVGTM FAGYLQTAVH 
181:	SSLNGKGGLS GWRWLFIIDG ILTIPLSLYG LFLFPDVPET TKAPYFTEQE KELSFKRLPA 
241:	RPKKKPLTLK AIKDIVRSWR IYGLCILWIF SGETQAIAVN VLMGQWMKWS NKFSVAQINN 
301:	YPTVITAVGV VSTLGASVIS DKLAGNPRWP FGLFLCVITT VSATILLAWN VPDGAKFFAY 
361:	FASGCTYAGQ AVWFSWANDI CRDNDQERGV VVFLMNMCQN IWHIWWAPIM YPNTDTPRFI 
421:	KGLIGLLVVG GIVFVSSCIV SYMQIRDKRI KRSIQDAKDF DDVFTEHESL ELKKIGKNDE 
481:	ESLNTTNAVK EISSPGLVIT RQRISMPKET NAQD