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2.A.1.14.19
Plasma membrane, high affinity vitamin H transporter 1 (H+:biotin symporter), Vht1 (Stolz, 2003)

Accession Number:O13880
Protein Name:Vht1
Length:568
Molecular Weight:62822.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Biotin, H+

Cross database links:

eggNOG: fuNOG07845
HEGENOM: HBG324575
RefSeq: NP_594801.1   
Entrez Gene ID: 2542518   
Pfam: PF07690   
KEGG: spo:SPAC1B3.16c   

Gene Ontology

GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015225 F:biotin transporter activity
GO:0015293 F:symporter activity
GO:0015878 P:biotin transport

References (2)

[1] “Isolation and characterization of the plasma membrane biotin transporter from Schizosaccharomyces pombe.”  Stolz J.et.al.   12557275
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASEWPETSR ASSVEENPKL NIPEIVESVS DSKPSLKNQF STTVIDSSDL NVFNDGAETT 
61:	VKEQEFTSSE LRRLQKLRLK MDLRIIPCLW ILYFLSCCLR FTVSLSFTMN TAQGHSLIQT 
121:	LSGYSAHYLA LGLALFYVGY IIFEVPSNLM MAFIEPRIWV SRIQLTIGVV GACHAVLGTK 
181:	HGNAQSYVAL RFFLGVAESG LWPGLAYYMS RWYRGKHLGK RIGWYYTAAQ IAAAAVSLVS 
241:	AGFQKMDGAR GLYGYQWMFL IWGVVAIAQA LSIPWWLPAV ASKEHRKSLS SFIPLPKWMK 
301:	TLSPQRIGFL TPADKSLHSR YIAEMNVGKR WQWSDLLKSC LDLRVWPFIL MYFGIVGVGN 
361:	GIFNYCTLII EEINPSFSGI DISLLNAPIW LADALGIVTV MPLYDRFHKK FSFFTGSCLI 
421:	IIAGLAVANY APRAWSRYGG LLMIGFGLGP TVPICMAWCS ASMAKTYGDV GVASSLALVT 
481:	GLGNLGSVVT TYALYSGWPG DPTFRKSNDV CIALIGVSII ACGIEFLLDK TGFGQFNASF 
541:	NNHDHEVEDE QEMTDIKPAL PSSQQADA