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2.A.1.14.21
The vesicular purine nucleotide (ADP, ATP, GTP) transporter. (Found in synaptic vesicles and chromafin granules, SLC17A9 (Sawada et al., 2008)).  Associated with disseminated superficial actinic porokeratosis (DSAP), a rare autosomal dominant genodermatosis (Cui et al. 2014).

Accession Number:Q9BYT1
Protein Name:SLC17A9
Length:436
Molecular Weight:47482.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ADP, ATP, GTP

Cross database links:

Genevestigator: Q9BYT1 Q9BYT1
eggNOG: prNOG12970 COG0477
RefSeq: NP_071365.3   
Entrez Gene ID: 63910   
Pfam: PF07690   
OMIM: 612107  gene
KEGG: hsa:63910    hsa:63910   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0006887 P:exocytosis
GO:0055085 P:transmembrane transport

References (10)

[1] “Identification of a vesicular nucleotide transporter.”  Sawada K.et.al.   18375752
[2] “Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.”  Jikuya H.et.al.   12693554
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Identification of a vesicular nucleotide transporter.”  Sawada K.et.al.   18375752
[7] “Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.”  Jikuya H.et.al.   12693554
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQPPPDEARR DMAGDTQWSR PECQAWTGTL LLGTCLLYCA RSSMPICTVS MSQDFGWNKK 
61:	EAGIVLSSFF WGYCLTQVVG GHLGDRIGGE KVILLSASAW GSITAVTPLL AHLSSAHLAF 
121:	MTFSRILMGL LQGVYFPALT SLLSQKVRES ERAFTYSIVG AGSQFGTLLT GAVGSLLLEW 
181:	YGWQSIFYFS GGLTLLWVWY VYRYLLSEKD LILALGVLAQ SRPVSRHNRV PWRRLFRKPA 
241:	VWAAVVSQLS AACSFFILLS WLPTFFEETF PDAKGWIFNV VPWLVAIPAS LFSGFLSDHL 
301:	INQGYRAITV RKLMQGMGLG LSSVFALCLG HTSSFCESVV FASASIGLQT FNHSGISVNI 
361:	QDLAPSCAGF LFGVANTAGA LAGVVGVCLG GYLMETTGSW TCLFNLVAII SNLGLCTFLV 
421:	FGQAQRVDLS STHEDL