TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.14.27
Voltage-driven Na+:phosphate cotransporter; solute carrier family 17, member 1.  Orthologous to 2.A.1.14.6.  Transports other anions including urate; functions in urate cell elimination at the renal apical membrane (Prestin et al. 2014).

Accession Number:Q14916
Protein Name:Sodium-dependent phosphate transport protein 1
Length:467
Molecular Weight:51132.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, phosphate, Urate

Cross database links:

Genevestigator: Q14916 Q14916
eggNOG: COG0477 COG0477
Entrez Gene ID: 6568   
Pfam: PF07690   
KEGG: hsa:6568    hsa:6568   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015321 F:sodium-dependent phosphate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport
GO:0046415 P:urate metabolic process

References (14)

[1] “Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23.”  Chong S.S.et.al.   8288239
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity.”  Soumounou Y.et.al.   11704559
[6] “Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene.”  Taketani Y.et.al.   9545579
[7] “Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression.”  Miyamoto K.et.al.   7826357
[8] “Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23.”  Chong S.S.et.al.   8288239
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity.”  Soumounou Y.et.al.   11704559
[13] “Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene.”  Taketani Y.et.al.   9545579
[14] “Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression.”  Miyamoto K.et.al.   7826357

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MQMDNRLPPK KVPGFCSFRY GLSFLVHCCN VIITAQRACL NLTMVVMVNS TDPHGLPNTS 
61:	TKKLLDNIKN PMYNWSPDIQ GIILSSTSYG VIIIQVPVGY FSGIYSTKKM IGFALCLSSV 
121:	LSLLIPPAAG IGVAWVVVCR AVQGAAQGIV ATAQFEIYVK WAPPLERGRL TSMSTSGFLL 
181:	GPFIVLLVTG VICESLGWPM VFYIFGACGC AVCLLWFVLF YDDPKDHPCI SISEKEYITS 
241:	SLVQQVSSSR QSLPIKAILK SLPVWAISTG SFTFFWSHNI MTLYTPMFIN SMLHVNIKEN 
301:	GFLSSLPYLF AWICGNLAGQ LSDFFLTRNI LSVIAVRKLF TAAGFLLPAI FGVCLPYLSS 
361:	TFYSIVIFLI LAGATGSFCL GGVFINGLDI APRYFGFIKA CSTLTGMIGG LIASTLTGLI 
421:	LKQDPESAWF KTFILMAAIN VTGLIFYLIV ATAEIQDWAK EKQHTRL