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2.A.1.14.28
Solute carrier family 17 (sodium phosphate), member 3.  Catalyzes voltage-driven Na+:phosphate cotransport, but also functions in cell elimination of urate at renal tubular cell apical membranes (Prestin et al. 2014).

Accession Number:O00476
Protein Name:Sodium-dependent phosphate transport protein 4
Length:420
Molecular Weight:46106.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Na+, phosphate, Urate

Cross database links:

Genevestigator: O00476 O00476
eggNOG: COG0477 COG0477
HEGENOM: HOG000230813 HOG000230813
Entrez Gene ID: 10786   
Pfam: PF07690   
KEGG: hsa:10786    hsa:10786   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0031526 C:brush border membrane
GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005887 C:integral to plasma membrane
GO:0048471 C:perinuclear region of cytoplasm
GO:0015238 F:drug transmembrane transporter activity
GO:0015562 F:efflux transmembrane transporter activity
GO:0008514 F:organic anion transmembrane transporter activity
GO:0005436 F:sodium:phosphate symporter activity
GO:0019534 F:toxin transporter activity
GO:0015143 F:urate transmembrane transporter activity
GO:0008308 F:voltage-gated anion channel activity
GO:0015760 P:glucose-6-phosphate transport
GO:0055085 P:transmembrane transport
GO:0046415 P:urate metabolic process

References (10)

[1] “A 1.1-Mb transcript map of the hereditary hemochromatosis locus.”  Ruddy D.A.et.al.   9149941
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic.”  Melis D.et.al.   15505377
[6] “A 1.1-Mb transcript map of the hereditary hemochromatosis locus.”  Ruddy D.A.et.al.   9149941
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic.”  Melis D.et.al.   15505377

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATKTELSPT ARESKNAQDM QVDETLIPRK VPSLCSARYG IALVLHFCNF TTIAQNVIMN 
61:	ITMVAMVNST SPQSQLNDSS EVLPVDSFGG LSKAPKSLPA KSSILGGQFA IWEKWGPPQE 
121:	RSRLCSIALS GMLLGCFTAI LIGGFISETL GWPFVFYIFG GVGCVCCLLW FVVIYDDPVS 
181:	YPWISTSEKE YIISSLKQQV GSSKQPLPIK AMLRSLPIWS ICLGCFSHQW LVSTMVVYIP 
241:	TYISSVYHVN IRDNGLLSAL PFIVAWVIGM VGGYLADFLL TKKFRLITVR KIATILGSLP 
301:	SSALIVSLPY LNSGYITATA LLTLSCGLST LCQSGIYINV LDIAPRYSSF LMGASRGFSS 
361:	IAPVIVPTVS GFLLSQDPEF GWRNVFFLLF AVNLLGLLFY LIFGEADVQE WAKERKLTRL