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2.A.1.14.30
Vesicular glutamate transporter 1, VGluT1. Brain-specific Na+-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7). Several proteins must be retrieved to the synatic vesicle before it can export neurotransmitters again, and cargo retrieval is a collective cargo-driven process, dependent on VGluT1 (Pan et al. 2015).

Accession Number:Q9P2U7
Protein Name:Vesicular glutamate transporter 1
Length:560
Molecular Weight:61613.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1
Substrate glutamate, phosphate, Na+

Cross database links:

Genevestigator: Q9P2U7
eggNOG: COG0477
HEGENOM: HOG000230812
Entrez Gene ID: 57030   
Pfam: PF07690   
KEGG: hsa:57030   

Gene Ontology

GO:0030054 C:cell junction
GO:0060203 C:clathrin sculpted glutamate transport vesicle membrane
GO:0060076 C:excitatory synapse
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0048786 C:presynaptic active zone
GO:0030672 C:synaptic vesicle membrane
GO:0019717 C:synaptosome
GO:0005315 F:inorganic phosphate transmembrane transporter activity
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0015321 F:sodium-dependent phosphate transmembrane transporter activity
GO:0015319 F:sodium:inorganic phosphate symporter activity
GO:0014047 P:glutamate secretion
GO:0051938 P:L-glutamate import
GO:0007616 P:long-term memory
GO:0007269 P:neurotransmitter secretion
GO:0060079 P:regulation of excitatory postsynaptic membrane potential
GO:0042137 P:sequestering of neurotransmitter
GO:0035249 P:synaptic transmission, glutamatergic

References (2)

[1] “Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter.”  Aihara Y.et.al.   10820226
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP VVDCTCFGLP 
61:	RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG HVVVQKAQFS WDPETVGLIH 
121:	GSFFWGYIVT QIPGGFICQK FAANRVFGFA IVATSTLNML IPSAARVHYG CVIFVRILQG 
181:	LVEGVTYPAC HGIWSKWAPP LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV 
241:	YGSFGIFWYL FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPLTK FSTPWRRFFT 
301:	SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV MTIIVPIGGQ 
361:	IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS KGVAISFLVL AVGFSGFAIS 
421:	GFNVNHLDIA PRYASILMGI SNGVGTLSGM VCPIIVGAMT KHKTREEWQY VFLIASLVHY 
481:	GGVIFYGVFA SGEKQPWAEP EEMSEEKCGF VGHDQLAGSD DSEMEDEAEP PGAPPAPPPS 
541:	YGATHSTFQP PRPPPPVRDY