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2.A.1.14.31
Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)

Accession Number:Q9P2U8
Protein Name:Vesicular glutamate transporter 2
Length:582
Molecular Weight:64392.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1
Substrate glutamate, Na+, phosphate

Cross database links:

Genevestigator: Q9P2U8
eggNOG: COG0477
HEGENOM: HOG000230812
Entrez Gene ID: 57084   
Pfam: PF07690   
KEGG: hsa:57084   

Gene Ontology

GO:0030054 C:cell junction
GO:0005769 C:early endosome
GO:0016021 C:integral to membrane
GO:0030672 C:synaptic vesicle membrane
GO:0019717 C:synaptosome
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006811 P:ion transport
GO:0001504 P:neurotransmitter uptake
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter.”  Aihara Y.et.al.   10820226
[2] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2).”  Takamori S.et.al.   11698620
[5] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL EVPERKAPLC 
61:	DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD 
121:	PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV 
181:	IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT 
241:	GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 
301:	TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT 
361:	IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV 
421:	GFSGFAISGF NVNHLDIAPR YASILMGISN GVGTLSGMVC PIIVGAMTKN KSREEWQYVF 
481:	LIAALVHYGG VIFYAIFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT 
541:	TKSYGATTQA NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS