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2.A.1.14.36
Thiamine pathway transporter THI73

Accession Number:Q07904
Protein Name:Thiamine pathway transporter THI73
Length:523
Molecular Weight:58531.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Thiamine, NONE

Cross database links:

Genevestigator: Q07904
eggNOG: COG0477
HEGENOM: HOG000171758
DIP: DIP-8846N
Entrez Gene ID: 850690   
Pfam: PF07690   
KEGG: sce:YLR004C   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (5)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[2] “Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w).”  Llorente B.et.al.   10869563
[3] “Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae.”  Nosaka K.et.al.   16194233
[4] “Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae.”  Mojzita D.et.al.   16850348
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNMSQRSMD VEKKAANADS CSVSTSSINV DDADVALRFL KQNGLDESST ANEDDVVAGE 
61:	EANFYGSHEL SPKVLRKVDL FILPFLCCTY LLMFLDKALL NYAASMGIKD HLKGNEFSNL 
121:	GTIFSAAYIF MEPVVTYLIQ KFPISKILGT FITVWGIVLA CHAACKTYAS LMVVRTLLGL 
181:	FESSSAVGCI AISGMYYTKS EQSARIGFWA TQAGTGYIVG GLISFGFLHY HGTAFTSWQI 
241:	MFLVVGLVTV AFGVLTFLYL PDNVTNAWFL NKEEKIQVVE HIRANQTGLE TKKFKKQQVK 
301:	ELFLHDKFTW PMLLLTACSQ ISTGAIGTFS VTITGTFGFD KYETALLQLP IGAITAMIIL 
361:	ITTQMLSRWG HITLITTSMY IPAIIGCIVL ISLPLSHKIG NLFSLYLLYS GSCVITNIYI 
421:	WNSCNTSGYT KRVFRNAITM IVYNVSCIIA PQMFRAYSAP RYIPAKIALL VTQCVCVPLQ 
481:	LYIGYICKKE NEKRDKEQEG QERKKYQFLD LTDIENRNFR YIY