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2.A.1.14.6
Na:Pi symporter, NPT1 or SLC17A1. (Renal chloride-dependent polyspecific anion exporter; transports organic acids such as p-aminohippurate, ureate, and acetylsalicylate (asprin)). Catalyzes ureate excretion. A mutant form shows increased risk of gout in humans.

Accession Number:Q61983
Protein Name:Npt1 aka SLC17A1
Length:465
Molecular Weight:51589.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate p-aminohippurate, Acetylsalicylate, Ureate

Cross database links:

Genevestigator: Q61983
HEGENOM: HBG561587
Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015114 F:phosphate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006817 P:phosphate transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter.”  Chong S.S.et.al.   7611445
[2] “Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity.”  Soumounou Y.et.al.   11704559
[3] “Interaction of the type IIa Na/Pi-cotransporter with PDZ proteins.”  Gisler S.M.et.al.   11099500

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MENQCLPKKV PGFCSFRYGL AILLHFCNIA IMAQRVCLNL TMVAMVNNTG SPHLSNESVV 
61:	EMLDNVKNPV YSWSPDIQGL ILSSVFFGMV VVQAPVGYLS GIYPMKRIIG SSLFLSSLMS 
121:	LLIPPAAQVG AALVIVCRVL QGIAQGTVST GQHEIWVKWA PPLERGRLTS MTLSGFVMGP 
181:	FIVLLVSGFI CDLLGWPMVF YIFGIVGCVL SLSWFFLFFD DPKDHPYMSS SEKDYIISSL 
241:	MQQASSGRQS LPIKAMLKSL PLWAIILNSF AFIWSNSLLV TYTPTFISTV LHVNVRENGL 
301:	LSSLPYLLAY ICGILAGQMS DFFLTRKIFS IVTVRKLFTT LGSFCPVIFI MCLLYLSYNF 
361:	YSTVIFLTLA NSTLSFSYCG QLINALDIAP RYYGFLKAVT ALIGMFGGLI SSTLAGLILN 
421:	QDPEYAWHKI SFLMAGINVT CLVFYFLFAK GEIQDWAKEI KTTRL