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2.A.1.15.2
MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate.  Transports 3HPP but not benzoate, 3-hydroxybenzoate or gentisate (Xu et al. 2013).  May also export arabinose but not xylose (Koita and Rao 2012).

Accession Number:P77589
Protein Name:MhpT aka B0353
Length:403
Molecular Weight:41551.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Arabinose

Cross database links:

Genevestigator: P77589
EchoBASE: EB3078
EcoGene: EG13293
HEGENOM: HBG715489
RefSeq: AP_001005.1    NP_414887.2   
Entrez Gene ID: 944997   
Pfam: PF07690   
BioCyc: EcoCyc:MHPT-MONOMER    ECOL168927:B0353-MONOMER   
KEGG: ecj:JW5046    eco:b0353   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity
GO:0055085 P:transmembrane transport

References (3)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTRTPSSSS SRLMLTIGLC FLVALMEGLD LQAAGIAAGG IAQAFALDKM QMGWIFSAGI 
61:	LGLLPGALVG GMLADRYGRK RILIGSVALF GLFSLATAIA WDFPSLVFAR LMTGVGLGAA 
121:	LPNLIALTSE AAGPRFRGTA VSLMYCGVPI GAALAATLGF AGANLAWQTV FWVGGVVPLI 
181:	LVPLLMRWLP ESAVFAGEKQ SAPPLRALFA PETATATLLL WLCYFFTLLV VYMLINWLPL 
241:	LLVEQGFQPS QAAGVMFALQ MGAASGTLML GALMDKLRPV TMSLLIYSGM LASLLALGTV 
301:	SSFNGMLLAG FVAGLFATGG QSVLYALAPL FYSSQIRATG VGTAVAVGRL GAMSGPLLAG 
361:	KMLALGTGTV GVMAASAPGI LVAGLAVFIL MSRRSRIQPC ADA