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2.A.1.15.3
2,4-Dichlorophenoxyacetate porter (Hawkins and Harwood 2002).

Accession Number:Q46M63
Protein Name:2,4-D transport protein
Length:460
Molecular Weight:47615.00
Species: [264198]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate 2,4-dichlorophenoxyacetate

Cross database links:

HEGENOM: HBG715489
RefSeq: YP_025390.1    YP_293624.1   
Entrez Gene ID: 2847414    3607893   
Pfam: PF07690   
BioCyc: REUT264198:REUT_D6469-MONOMER   
KEGG: reu:Reut_D6469   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (5)

[1] “Analysis, cloning, and high-level expression of 2,4-dichlorophenoxyacetate monooxygenase gene tfdA of Alcaligenes eutrophus JMP134.”  Streber W.R.et.al.   3036764
[2] “Nucleotide sequence of IS402 from Pseudomonas cepacia.”  Ferrante A.A.et.al.   1650732
[3] “Purification and characterization of maleylacetate reductase from Alcaligenes eutrophus JMP134(pJP4).”  Seibert V.et.al.   8226615
[4] “The tfdR gene product can successfully take over the role of the insertion element-inactivated TfdT protein as a transcriptional activator of the tfdCDEF gene cluster, which encodes chlorocatechol degradation in Ralstonia eutropha JMP134(pJP4).”  Leveau J.H.et.al.   8955303
[5] “Genetic organization of the catabolic plasmid pJP4 from Ralstonia eutropha JMP134 (pJP4) reveals mechanisms of adaptation to chloroaromatic pollutants and evolution of specialized chloroaromatic degradation pathways.”  Trefault N.et.al.   15186344

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNTTIDITDV IEKQSPNRTV GTLLVLSFLI MLCDGYDLQA IAFASPTIIA SWGIEKASFG 
61:	FIFSAGLLGV MLGGFLFGYL ADRIGRRPAL LLGTFIFSAF TLAAVLATNV TELAALRFFA 
121:	GLGIGGITPI CFALNVEYVP KRFHASVVGV VMIGYVIGIS VGGLFAAWLV PVFGWQVLFY 
181:	IGGLAPLVLL PILAIALPES IKYLVLAGRG GDTIARIVNA IDPSAQANAQ TRFVLEAEEA 
241:	RAKVGGWKES VKALFRGRLS RITPVLWLAF IANSVTVFFL ASWIPVLTVG TGRPATLAAI 
301:	GLTLFSAGGA FGGLFASRLI DRFGVGAMGA VPLVAAVFVV AVGSMAFSDT GFLSMLFIVG 
361:	FFVLGGHVGL MGSMGLFYAN ANRANGVGWA ISIGKLGSII GPAIAGILIA ANASIGTLFM 
421:	AAAAPLLIAG AGVVLLGRLQ KASDLAHATT AGHVADPLVS