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2.A.1.15.9
Probable 4-methylmuconolactone transporter, MmlH (Erb et al., 1998)

Accession Number:O51798
Protein Name:MmlH
Length:428
Molecular Weight:45804.00
Species:Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [264198]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate 4-methylmuconolactone

Cross database links:

HEGENOM: HBG757988
RefSeq: YP_295715.1   
Entrez Gene ID: 3609833   
Pfam: PF07690   
BioCyc: REUT264198:REUT_A1504-MONOMER   
KEGG: reu:Reut_A1504   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (1)

[1] “Characterization of a gene cluster from Ralstonia eutropha JMP134 encoding metabolism of 4-methylmuconolactone.”  Erb R.W.et.al.   9461415

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFAWYKAGSP QQKKTFWACY SGWALDSFDM QMFSFLLPAL TLTWGLTKAE VGVLGTVALV 
61:	VTAIGGWGAG ILSDRYGRAR ILVLAIIWFT LFGVLAGFAQ SYQQLLIART LQGLGFGGEW 
121:	AVGAALMAEV IDSRHRGKAI GFVQSGFALG WALAVVVATL LLAWLPKEMA WRVAFWSGII 
181:	PALIVLFIRR HVKDSSMFER ARQSRAPRAS LSSVFNRKYA RTLALSSVLV IGLQAGCYAI 
241:	LVWLPSLLNQ RQVAAGSMIV TVFIMAFGSF CGFAVTADLS DRIGRRPTLI LLSVCAWIVT 
301:	VSYMLLPLNT TLTAILGFLV GFSAIGMFAA LGPFLSELFP TNVRTTCMGF AYNVGKSIGA 
361:	GSVVGVGVLS THIGLANAMG TFCLVAYAFA VFGIMLLPET RGIAIENIGE ADAHSPAAPL 
421:	AQPASARS