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2.A.1.16.1
Siderophore-iron (ferrioxamine):H+ symporter, Sit1 (Arn3) (in vesicles)

Accession Number:P39980
Protein Name:YEH5 aka YEL065W aka Sit1
Length:628
Molecular Weight:70562.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Fe3+-ferrixoamine, H+

Cross database links:

Genevestigator: P39980
eggNOG: fuNOG06310
HEGENOM: HBG325340
DIP: DIP-7273N
RefSeq: NP_010849.1   
Entrez Gene ID: 856644   
KEGG: sce:YEL065W   

Gene Ontology

GO:0016023 C:cytoplasmic membrane-bounded vesicle
GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0015344 F:siderophore-iron (ferrioxamine) uptake tran...
GO:0015892 P:siderophore-iron transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.”  Yun C.-W.et.al.   10744769
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[3] “Siderophore-mediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily.”  Lesuisse E.et.al.   9884238
[4] “Siderophore-iron uptake in Saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters.”  Yun C.-W.et.al.   10748025

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDPGIANHTL PEEFEEVVVP EMLEKEVGAK VDVKPTLTTS SPAPSYIELI DPGVHNIEIY 
61:	AEMYNRPIYR VALFFSLFLI AYAYGLDGNI RYTFQAYATS SYSQHSLLST VNCIKTVIAA 
121:	VGQIFFARLS DIFGRFSIMI VSIIFYSMGT IIESQAVNIT RFAVGGCFYQ LGLTGIILIL 
181:	EVIASDFSNL NWRLLALFIP ALPFIINTWI SGNVTSAIDA NWKWGIGMWA FILPLACIPL 
241:	GICMLHMRYL ARKHAKDRLK PEFEALNKLK WKSFCIDIAF WKLDIIGMLL ITVFFGCVLV 
301:	PFTLAGGLKE EWKTAHIIVP EVIGWVVVLP LYMLWEIKYS RHPLTPWDLI QDRGIFFALL 
361:	IAFFINFNWY MQGDYMYTVL VVAVHESIKS ATRITSLYSF VSVIVGTILG FILIKVRRTK 
421:	PFIIFGISCW IVSFGLLVHY RGDSGAHSGI IGSLCLLGFG AGSFTYVTQA SIQASAKTHA 
481:	RMAVVTSLYL ATYNIGSAFG SSVSGAVWTN ILPKEISKRI SDPTLAAQAY GSPFTFITTY 
541:	TWGTPERIAL VMSYRYVQKI LCIIGLVFCF PLLGCAFMLR NHKLTDSIAL EGNDHLESKN 
601:	TFEIEEKEES FLKNKFFTHF TSSKDRKD