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2.A.1.16.2
The ferric enterobactin:H+ symporter, Enb1

Accession Number:Q08299
Protein Name:Enb1 aka YOL158c
Length:606
Molecular Weight:66970.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Fe3+-enterobactin, H+

Cross database links:

Genevestigator: Q08299
eggNOG: fuNOG06310
RefSeq: NP_014484.1   
Entrez Gene ID: 854007   
Pfam: PF07690   
KEGG: sce:YOL158C   

Gene Ontology

GO:0016023 C:cytoplasmic membrane-bounded vesicle
GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0015620 F:ferric-enterobactin transmembrane transport...
GO:0015685 P:ferric-enterobactin transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.”  Yun C.-W.et.al.   10744769
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[3] “The response to iron deprivation in Saccharomyces cerevisiae: expression of siderophore-based systems of iron uptake.”  Philpott C.C.et.al.   12196168
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[5] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.”  Chi A.et.al.   17287358

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLETDHSRND NLDDKSTVCY SEKTDSNVEK STTSGLRRID AVNKVLSDYS SFTAFGVTFS 
61:	SLKTALLVAL FLQGYCTGLG GQISQSIQTY AANSFGKHSQ VGSINTVKSI VASVVAVPYA 
121:	RISDRFGRIE CWIFALVLYT IGEIISAATP TFSGLFAGIV IQQFGYSGFR LLATALTGDL 
181:	SGLRDRTFAM NIFLIPVIIN TWVSGNIVSS VAGNVAPYKW RWGYGIFCII VPISTLILVL 
241:	PYVYAQYISW RSGKLPPLKL KEKGQTLRQT LWKFADDINL IGVILFTAFL VLVLLPLTIA 
301:	GGATSKWREG HIIAMIVVGG CLGFIFLIWE LKFAKNPFIP RVYLGDPTIY VALLMEFVWR 
361:	LGLQIELEYL VTVLMVAFGE STLSAQRIAQ LYNFLQSCTN IVVGIMLHFY PHPKVFVVAG 
421:	SLLGVIGMGL LYKYRVVYDG ISGLIGAEIV VGIAGGMIRF PMWTLVHAST THNEMATVTG 
481:	LLMSVYQIGD AVGASIAGAI WTQRLAKELI QRLGSSLGMA IYKSPLNYLK KYPIGSEVRV 
541:	QMIESYSKIQ RLLIIVSISF AAFNAVLCFF LRGFTVNKKQ SLSAEEREKE KLKIKQQSWL 
601:	RRVIGY