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2.A.1.19.1
The basolateral multivalent, potential-sensitive, organic cation (tetramethyl-ammonium; N'-methylnicotinamide; cationic drugs, xenobiotics, vitamins, neuro-transmitters, etc.) transporter (uni-porter)-1, Oct1.  Cysteyl residues essential for transport and substrate binding have been identified (Sturm et al. 2007).

Accession Number:Q63089
Protein Name:Oct1
Length:556
Molecular Weight:61541.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Tetramethylammonium, N'-methylnicotinamide, xenobiotics, Vitamins, Neurotransmitters

Cross database links:

Genevestigator: Q63089
eggNOG: maNOG14992
RefSeq: NP_036829.1   
Entrez Gene ID: 24904   
Pfam: PF00083   
KEGG: rno:24904   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005329 F:dopamine transmembrane transporter activity
GO:0005333 F:norepinephrine transmembrane transporter ac...
GO:0015651 F:quaternary ammonium group transmembrane tra...
GO:0015872 P:dopamine transport
GO:0048241 P:epinephrine transport
GO:0015874 P:norepinephrine transport
GO:0015697 P:quaternary ammonium group transport
GO:0055085 P:transmembrane transport

References (18)

[1] “Drug excretion mediated by a new prototype of polyspecific transporter.”  Gruendemann D.et.al.   7990927
[2] “Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).”  Zhang L.et.al.   9195965
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1.”  Busch A.E.et.al.   8955087
[5] “Membrane localization of the electrogenic cation transporter rOCT1 in rat liver.”  Meyer-Wentrup F.et.al.   9703985
[6] “Catecholamine transport by the organic cation transporter type 1 (OCT1).”  Breidert T.et.al.   9776363
[7] “Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.”  Urakami Y.et.al.   9808712
[8] “Localization of organic cation transporters OCT1 and OCT2 in rat kidney.”  Karbach U.et.al.   10997918
[9] “Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.”  Arndt P.et.al.   11502595
[10] “Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels.”  Slitt A.L.et.al.   11792693
[11] “Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis.”  Denk G.U.et.al.   15122767
[12] “Purification and functional reconstitution of the rat organic cation transporter OCT1.”  Keller T.et.al.   16142924
[13] “Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.”  Ishiguro N.et.al.   15640376
[14] “Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.”  Kimura N.et.al.   16272756
[15] “Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation.”  Ciarimboli G.et.al.   15829703
[16] “Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.”  Amphoux A.et.al.   16581093
[17] “Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.”  Sturm A.et.al.   17567940
[18] “Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats.”  Maeda T.et.al.   17553914

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPTVDDVLEQ VGEFGWFQKQ AFLLLCLISA SLAPIYVGIV FLGFTPGHYC QNPGVAELSQ 
61:	RCGWSQAEEL NYTVPGLGPS DEASFLSQCM RYEVDWNQST LDCVDPLSSL VANRSQLPLG 
121:	PCEHGWVYDT PGSSIVTEFN LVCGDAWKVD LFQSCVNLGF FLGSLVVGYI ADRFGRKLCL 
181:	LVTTLVTSVS GVLTAVAPDY TSMLLFRLLQ GMVSKGSWVS GYTLITEFVG SGYRRTTAIL 
241:	YQMAFTVGLV GLAGVAYAIP DWRWLQLAVS LPTFLFLLYY WFVPESPRWL LSQKRTTRAV 
301:	RIMEQIAQKN GKVPPADLKM LCLEEDASEK RSPSFADLFR TPNLRKHTVI LMYLWFSCAV 
361:	LYQGLIMHVG ATGANLYLDF FYSSLVEFPA AFIILVTIDR IGRIYPIAAS NLVTGAACLL 
421:	MIFIPHELHW LNVTLACLGR MGATIVLQMV CLVNAELYPT FIRNLGMMVC SALCDLGGIF 
481:	TPFMVFRLME VWQALPLILF GVLGLTAGAM TLLLPETKGV ALPETIEEAE NLGRRKSKAK 
541:	ENTIYLQVQT GKSSST