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2.A.1.19.10
The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (Km = 1 µM), dehydroepiandrosterone sulfate (Km = 60µM), many anionic drugs, diuretics, bile salts, urate and ochratoxin A). Catalyzes Na+-independent efflux, possibly using glutamate as a counter anion in an exchange reaction, especially in the placenta (Lofthouse et al. 2015).  Functions in renal urate reabsorption (Prestin et al. 2014).

Accession Number:Q9NSA0
Protein Name:OAT4 aka HOAT4
Length:550
Molecular Weight:59972.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Estrone sulfate, Dehydroepiandrosterone sulfate, Anionic drugs, Diuretics, bile salts, Urate, Ochratoxin A, Na+, glutamate

Cross database links:

Genevestigator: Q9NSA0 Q9NSA0
eggNOG: prNOG10165 COG0477
HEGENOM: HBG713776 HOG000234569
RefSeq: NP_060954.1   
Entrez Gene ID: 55867   
Pfam: PF00083   
Drugbank: Drugbank Link   
OMIM: 607097  gene
KEGG: hsa:55867    hsa:55867   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0009897 C:external side of plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005452 F:inorganic anion exchanger activity
GO:0005515 F:protein binding
GO:0015347 F:sodium-independent organic anion transmembr...
GO:0015711 P:organic anion transport
GO:0015347 F:sodium-independent organic anion transmembrane transporter activity
GO:0046415 P:urate metabolic process

References (14)

[1] “Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.”  Cha S.H.et.al.   10660625
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4).”  Zhou F.et.al.   15291761
[6] “The role of glycine residues in the function of human organic anion transporter 4.”  Zhou F.et.al.   15102942
[7] “The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.”  Zhou F.et.al.   15576633
[8] “Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.”  Cha S.H.et.al.   10660625
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4).”  Zhou F.et.al.   15291761
[13] “The role of glycine residues in the function of human organic anion transporter 4.”  Zhou F.et.al.   15102942
[14] “The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.”  Zhou F.et.al.   15576633

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW THMLDNGSAV 
61:	STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA TATSWSEADT EPCVDGWVYD 
121:	RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM SGILVGSFIW GLLSYRFGRK PMLSWCCLQL 
181:	AVAGTSTIFA PTFVIYCGLR FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA 
241:	GQAALGGLAF ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA 
301:	RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML VVNFSLLISY 
361:	YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG RRTIQAGSQA MAGLAILANM 
421:	LVPQDLQTLR VVFAVLGKGC FGISLTCLTI YKAELFPTPV RMTADGILHT VGRLGAMMGP 
481:	LILMSRQALP LLPPLLYGVI SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ 
541:	EAVTVESTSL