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2.A.1.19.12
The high affinity L-carnitine transporter, CT2 (present in the luminal membranes of epididymal epithelia and Sertoli cells of the testis) (Enomoto et al., 2002b)

Accession Number:Q86VW1
Protein Name:Solute carrier family 22 member 16
Length:577
Molecular Weight:64614.00
Species: [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate L-carnitine

Cross database links:

COG0477
Genevestigator: Q86VW1 Q86VW1
RefSeq: NP_149116.2   
Entrez Gene ID: 85413   
Pfam: PF00083   
OMIM: 608276  gene
KEGG: hsa:85413    hsa:85413   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015226 F:carnitine transporter activity
GO:0046717 P:acid secretion
GO:0015879 P:carnitine transport
GO:0030154 P:cell differentiation
GO:0007275 P:multicellular organismal development
GO:0007338 P:single fertilization
GO:0030317 P:sperm motility
GO:0007283 P:spermatogenesis

References (18)

[1] “Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.”  Eraly S.A.et.al.   12372408
[2] “Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias.”  Gong S.et.al.   12384147
[3] “Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.”  Enomoto A.et.al.   12089149
[4] “Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.”  Okabe M.et.al.   15963465
[5] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “Expression of organic cation transporter SLC22A16 in human endometria.”  Sato N.et.al.   17197897
[9] “Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.”  Ota K.et.al.   17581421
[10] “Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.”  Eraly S.A.et.al.   12372408
[11] “Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias.”  Gong S.et.al.   12384147
[12] “Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.”  Enomoto A.et.al.   12089149
[13] “Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.”  Okabe M.et.al.   15963465
[14] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[16] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[17] “Expression of organic cation transporter SLC22A16 in human endometria.”  Sato N.et.al.   17197897
[18] “Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.”  Ota K.et.al.   17581421

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGSRHFEGIY DHVGHFGRFQ RVLYFICAFQ NISCGIHYLA SVFMGVTPHH VCRPPGNVSQ 
61:	VVFHNHSNWS LEDTGALLSS GQKDYVTVQL QNGEIWELSR CSRNKRENTS SLGYEYTGSK 
121:	KEFPCVDGYI YDQNTWKSTA VTQWNLVCDR KWLAMLIQPL FMFGVLLGSV TFGYFSDRLG 
181:	RRVVLWATSS SMFLFGIAAA FAVDYYTFMA ARFFLAMVAS GYLVVGFVYV MEFIGMKSRT 
241:	WASVHLHSFF AVGTLLVALT GYLVRTWWLY QMILSTVTVP FILCCWVLPE TPFWLLSEGR 
301:	YEEAQKIVDI MAKWNRASSC KLSELLSLDL QGPVSNSPTE VQKHNLSYLF YNWSITKRTL 
361:	TVWLIWFTGS LGFYSFSLNS VNLGGNEYLN LFLLGVVEIP AYTFVCIAMD KVGRRTVLAY 
421:	SLFCSALACG VVMVIPQKHY ILGVVTAMVG KFAIGAAFGL IYLYTAELYP TIVRSLAVGS 
481:	GSMVCRLASI LAPFSVDLSS IWIFIPQLFV GTMALLSGVL TLKLPETLGK RLATTWEEAA 
541:	KLESENESKS SKLLLTTNNS GLEKTEAITP RDSGLGE