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2.A.1.19.12
The high affinity L-carnitine transporter, CT2, present in the luminal membranes of epididymal epithelia and Sertoli cells of the testis (Enomoto et al., 2002b).  It also catalyzes uptake of the anticancer polyamine analogue, bleomycin-A5 (Aouida et al. 2010). Carnitine uptake and metabolism have been reviewed (Nałęcz and Nałęcz 2017).

Accession Number:Q86VW1
Protein Name:Solute carrier family 22 member 16
Length:577
Molecular Weight:64614.00
Species: [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate L-carnitine

Cross database links:

COG0477
Genevestigator: Q86VW1 Q86VW1
RefSeq: NP_149116.2   
Entrez Gene ID: 85413   
Pfam: PF00083   
OMIM: 608276  gene
KEGG: hsa:85413    hsa:85413   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015226 F:carnitine transporter activity
GO:0046717 P:acid secretion
GO:0015879 P:carnitine transport
GO:0030154 P:cell differentiation
GO:0007275 P:multicellular organismal development
GO:0007338 P:single fertilization
GO:0030317 P:sperm motility
GO:0007283 P:spermatogenesis

References (18)

[1] “Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.”  Eraly S.A.et.al.   12372408
[2] “Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias.”  Gong S.et.al.   12384147
[3] “Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.”  Enomoto A.et.al.   12089149
[4] “Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.”  Okabe M.et.al.   15963465
[5] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “Expression of organic cation transporter SLC22A16 in human endometria.”  Sato N.et.al.   17197897
[9] “Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.”  Ota K.et.al.   17581421
[10] “Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.”  Eraly S.A.et.al.   12372408
[11] “Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias.”  Gong S.et.al.   12384147
[12] “Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.”  Enomoto A.et.al.   12089149
[13] “Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.”  Okabe M.et.al.   15963465
[14] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[16] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[17] “Expression of organic cation transporter SLC22A16 in human endometria.”  Sato N.et.al.   17197897
[18] “Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.”  Ota K.et.al.   17581421

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGSRHFEGIY DHVGHFGRFQ RVLYFICAFQ NISCGIHYLA SVFMGVTPHH VCRPPGNVSQ 
61:	VVFHNHSNWS LEDTGALLSS GQKDYVTVQL QNGEIWELSR CSRNKRENTS SLGYEYTGSK 
121:	KEFPCVDGYI YDQNTWKSTA VTQWNLVCDR KWLAMLIQPL FMFGVLLGSV TFGYFSDRLG 
181:	RRVVLWATSS SMFLFGIAAA FAVDYYTFMA ARFFLAMVAS GYLVVGFVYV MEFIGMKSRT 
241:	WASVHLHSFF AVGTLLVALT GYLVRTWWLY QMILSTVTVP FILCCWVLPE TPFWLLSEGR 
301:	YEEAQKIVDI MAKWNRASSC KLSELLSLDL QGPVSNSPTE VQKHNLSYLF YNWSITKRTL 
361:	TVWLIWFTGS LGFYSFSLNS VNLGGNEYLN LFLLGVVEIP AYTFVCIAMD KVGRRTVLAY 
421:	SLFCSALACG VVMVIPQKHY ILGVVTAMVG KFAIGAAFGL IYLYTAELYP TIVRSLAVGS 
481:	GSMVCRLASI LAPFSVDLSS IWIFIPQLFV GTMALLSGVL TLKLPETLGK RLATTWEEAA 
541:	KLESENESKS SKLLLTTNNS GLEKTEAITP RDSGLGE