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2.A.1.19.15
The liver multispecific organic anion transporter, NLT or OAT2. Transports salicylate, KM=90┬ÁM, acetylsalicylate, prostaglandin E2, dicarboxylate, p-aminohippurate, etc. (Sekine et al., 1998)

Accession Number:Q5RLM2
Protein Name:Solute carrier family 22 member 7
Length:535
Molecular Weight:58654.00
Species: [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Salicylate, Acetylsalicylate, Prostaglandin E2, Dicarboxylates, p-aminohippurate,

Cross database links:

Genevestigator: Q5RLM2
eggNOG: maNOG07826
RefSeq: NP_445989.2   
Entrez Gene ID: 89776   
Pfam: PF00083   
KEGG: rno:89776   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0008514 F:organic anion transmembrane transporter act...
GO:0015711 P:organic anion transport

References (4)

[1] “Molecular cloning and characterization of a novel liver-specific transport protein.”  Simonson G.D.et.al.   8056831
[2] “Identification of multispecific organic anion transporter 2 expressed predominantly in the liver.”  Sekine T.et.al.   9650585
[3] “Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells.”  Morita N.et.al.   11504818
[4] “Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen.”  Morita N.et.al.   15900017

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGFEDLLDKV GGFGPFQLRN LVLMALPRML LPMHFLLPVF MAAVPAHHCA LPGAPANLSH 
61:	QDLWLEAHLP RETDGSFSSC LRFAYPQTVP NVTLGTEVSN SGEPEGEPLT VPCSQGWEYD 
121:	RSEFSSTIAT EWDLVCQQRG LNKITSTCFF IGVLVGAVVY GYLSDRFGRR RLLLVAYVSS 
181:	LVLGLMSAAS INYIMFVVTR TLTGSALAGF TIIVLPLELE WLDVEHRTVA GVISTVFWSG 
241:	GVLLLALVGY LIRSWRWLLL AATLPCVPGI ISIWWVPESA RWLLTQGRVE EAKKYLLSCA 
301:	KLNGRPVGEG SLSQEALNNV VTMERALQRP SYLDLFRTSQ LRHISLCCMM VWFGVNFSYY 
361:	GLTLDVSGLG LNVYQTQLLF GAVELPSKIM VYFLVRRLGR RLTEAGMLLG AALTFGTSLL 
421:	VSLETKSWIT ALVVVGKAFS EAAFTTAYLF TSELYPTVLR QTGLGLTALM GRLGASLAPL 
481:	AALLDGVWLL LPKVAYGGIA LVAACTALLL PETKKAQLPE TIQDVERKST QEEDV