TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.19.16
The organic anion transporter, Oat6 (binding and transport rates for 40 anionic substrates were studied and compared with these for Oat1 (TC# 1.A.1.19.4) (Kaler et al., 2007); transports many antiviral agents (Truong et al., 2008).

Accession Number:Q80UJ1
Protein Name:Organic anion transporter 6 aka Oat6
Length:556
Molecular Weight:60944.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Organic anions, Antivirals

Cross database links:

Genevestigator: Q80UJ1
eggNOG: roNOG12130
HEGENOM: HBG713776
RefSeq: NP_941052.1   
Entrez Gene ID: 381203   
Pfam: PF00083   
KEGG: mmu:381203   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008514 F:organic anion transmembrane transporter act...
GO:0015711 P:organic anion transport

References (6)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa.”  Monte J.C.et.al.   15369770
[3] “Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).”  Schnabolk G.W.et.al.   16478971
[4] “Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions.”  Kaler G.et.al.   17094945
[5] “Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.”  Kaler G.et.al.   17553798
[6] “Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination.”  Truong D.M.et.al.   18174163

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAFTDLLDAL GGVGRFQLVY TALLLLPCGL LACHTFLQNF TAAAPPHHCQ HPANYTEPTT 
61:	NVSGVWLRAA IPLNQHGDPE PCRRYVEPQW ALLKPNASSH GVATEGCKDG WVYDRSIFPS 
121:	TIVMEWDLVC EARTLRDLAQ SIYMSGVLVG AALFGGLADR LGRKAPLVWS YLQLAVSGAA 
181:	TAYVGSFSAY CVFRFLMGMT FSGIILNSLS LVVEWMPTRG RTVAGILLGF SFTLGQLILA 
241:	GVAYLIRPWR WLQFAVSAPF LVFFLYSWWL PESSRWLLLH GKAQQAVQNL QKVAMMNGRK 
301:	AEGERLTTEV VSSYIQDEFA SVRTSNSILD LFRTPAIRRV TCCLMGVWFS NSVAYYGLAM 
361:	DLQKFGLSIY LVQALFGIID IPAMLVATTT MIYVGRRATV SSFLILAGLM VIANMFMPED 
421:	LQTLRTVQAA LGKGCLASSF ICVYLFTGEL YPTEIRQMGM GFASVNARLG GLVAPLITTL 
481:	GEISPVLPPV SFGATSVLAG MAVACFLTET RNVPLVETIA AMERRVKQGR SKRDTEQKSE 
541:	EISLQQLGAS PLKETI