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2.A.1.19.17
Kidney organic cation transporter-like 3 ORCTL-3 (OAT10; SLC22A13; Like-3) (Bahn et al., 2008) (transports nicotinate, p-aminohippurate and urate; KM=20-40 mμM) via exchange for lactate).  Activated by tumorigeneic mutations in this antitumor gene to promote apoptosis (AbuAli and Grimm 2014).  Functions in urate reabsorption (Prestin et al. 2014).

Accession Number:Q9Y226
Protein Name:ORCTL-3 aka SLC22A13
Length:551
Molecular Weight:60862.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Nicotinate, Urate, Lactate, p-aminohippurate

Cross database links:

Genevestigator: Q9Y226 Q9Y226
eggNOG: prNOG10639 COG0477
HEGENOM: HBG713776 HOG000234569
RefSeq: NP_004247.2   
Entrez Gene ID: 9390   
Pfam: PF00083   
OMIM: 604047  gene
KEGG: hsa:9390    hsa:9390   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015101 F:organic cation transmembrane transporter ac...
GO:0015695 P:organic cation transport
GO:0015101 F:organic cation transmembrane transporter activity

References (8)

[1] “Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.”  Nishiwaki T.et.al.   10072596
[2] “Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.”  Daigo Y.et.al.   10231028
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.”  Nishiwaki T.et.al.   10072596
[6] “Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.”  Daigo Y.et.al.   10231028
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC AVAWVKNHTF 
61:	NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS HRFNETQPCD MGWEYPENRL 
121:	PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV GTLMFGPLCD RIGRKATILA QLLLFTLIGL 
181:	ATAFVPSFEL YMALRFAVAT AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL 
241:	AGLAYGFRNW RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR 
301:	KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG LSLQVGDFGL 
361:	DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG GLMCIIIIFI PADLPVVVTM 
421:	LAVVGKMATA AAFTISYVYS AELFPTILRQ TGMGLVGIFS RIGGILTPLV ILLGEYHAAL 
481:	PMLIYGSLPI VAGLLCTLLP ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS 
541:	PGVAFVSSTY F