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2.A.1.19.20
Prostaglandin (PGE2, PGE2α, and PGD(2)) -specific organic anion transporter. Exhibits Na+ -independent and saturable transport. Shows narrow substrate selectivity and high affinity (Shiraya et al., 2010).

Accession Number:Q8R0S9
Protein Name:BC026439 protein
Length:554
Molecular Weight:62424.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Substrate Prostaglandin E2, Prostaglandin E2 alpha, Prostaglandin 2

Cross database links:

Genevestigator: Q8R0S9 Q8R0S9
eggNOG: KOG0255 KOG0255
HEGENOM: HBG713776 HBG713776
Entrez Gene ID: 210463   
Pfam: PF07690   
KEGG: mmu:210463    mmu:210463   

Gene Ontology

GO:0016020 C:membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (14)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.”  Mural R.J.et.al.   12040188
[3] “A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.”  Shiraya K.et.al.   20448048
[4] “High-efficiency full-length cDNA cloning.”  Carninci P.et.al.   10349636
[5] “Antisense Transcription in the Mammalian Transcriptome.”  RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortiumet.al.   16141073
[6] “Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.”  Carninci P.et.al.   11042159
[7] “RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.”  Shibata K.et.al.   11076861
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.”  Mural R.J.et.al.   12040188
[10] “A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.”  Shiraya K.et.al.   20448048
[11] “High-efficiency full-length cDNA cloning.”  Carninci P.et.al.   10349636
[12] “Antisense Transcription in the Mammalian Transcriptome.”  RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortiumet.al.   16141073
[13] “Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.”  Carninci P.et.al.   11042159
[14] “RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.”  Shibata K.et.al.   11076861

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDFDEILHHV GDSGRFQICM IILLNILSLV LSPHDVLENF TAAIPAHHCS INLDNSRSEV 
61:	STDMNLTTED LMKVSIPMGP NQKPEQCRRF RYTQWQFLDS NISTFNSTEL ETEPCLDGWT 
121:	YDHSVFTSTI VTEWDLVCDF QSFKYYAQAT SLAGHLVSCP LSGIISDRFG RKPLLMYCSL 
181:	AYGAVGTYCA FAPNFSVYCV LRFLLSAFQS TILINSLILV LEEASVQWHP TIIVLSGLFN 
241:	SIGQGVLGGL AYVISDWHLL QLAYALPFFI FFVLFCWVPE SVRWLIITGK TDQAWKELQR 
301:	IASINGKKGI AQNLTTEDLR SKLKKDVNST GKLFRIKDIF INPLIRKIVL SNSSLLFAEL 
361:	FSFVGLLLDV QLLGKNMFLT QIFLGAIDVP SKSLTYFTIR NVSRRPLIAF LLLTTGSCIT 
421:	ITIFISEEMY VLRTIIFILG KGCFAAFTCI STTYINELSP VELRSTLNGV FLAVVRLAGV 
481:	LSALTLATRK YFVYLPMILY GVLPIVATIS ILFLPETFNL PHTDIIKDME KRKRLMSKNI 
541:	SKKEGQDFLE TTEC