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2.A.1.19.22
solute carrier family 22, member 14, Slc22a14, is crucial for sperm motility and male fertility in mice. It is expressed specifically in male germ cells, and mice lacking the Slc22a14 gene show severe male infertility as well as sperm morphological changes (Maruyama et al. 2016).

Accession Number:Q9Y267
Protein Name:Solute carrier family 22 member 14
Length:594
Molecular Weight:66684.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown, NONE

Cross database links:

Genevestigator: Q9Y267 Q9Y267
eggNOG: COG0477 COG0477
HEGENOM: HOG000234569 HOG000234569
Entrez Gene ID: 9389   
Pfam: PF00083   
KEGG: hsa:9389    hsa:9389   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015101 F:organic cation transmembrane transporter activity

References (10)

[1] “Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.”  Nishiwaki T.et.al.   10072596
[2] “Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.”  Daigo Y.et.al.   10231028
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.”  Nishiwaki T.et.al.   10072596
[7] “Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.”  Daigo Y.et.al.   10231028
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGEENFKEE LRSQDASRNL NQHEVAGHPH SWSLEMLLRR LRAVHTKQDD KFANLLDAVG 
61:	EFGTFQQRLV ALTFIPSIMS AFFMFADHFV FTAQKPYCNT SWILAVGPHL SKAEQLNLTI 
121:	PQAPNGSFLT CFMYLPVPWN LDSIIQFGLN DTDTCQDGWI YPDAKKRSLI NEFDLVCGME 
181:	TKKDTAQIMF MAGLPIGSLI FRLITDKMGR YPAILLSLLG LIIFGFGTAF MNSFHLYLFF 
241:	RFGISQSVVG YAISSISLAT EWLVGEHRAH AIILGHCFFA VGAVLLTGIA YSLPHWQLLF 
301:	LVGGILVIPF ISYIWILPES PRWLMMKGKV KEAKQVLCYA ASVNKKTIPS NLLDELQLPR 
361:	KKVTRASVLD FCKNRQLCKV TLVMSCVWFT VSYTYFTLSL RMRELGVSVH FRHVVPSIME 
421:	VPARLCCIFL LQQIGRKWSL AVTLLQAIIW CLLLLFLPEG EDGLRLKWPR CPATELKSMT 
481:	ILVLMLREFS LAATVTVFFL YTAELLPTVL RATGLGLVSL ASVAGAILSL TIISQTPSLL 
541:	PIFLCCVLAI VAFSLSSLLP ETRDQPLSES LNHSSQIRNK VKDMKTKETS SDDV