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2.A.1.19.24
Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3)

Accession Number:O75751
Protein Name:Solute carrier family 22 member 3
Length:556
Molecular Weight:61280.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Monoamines

Cross database links:

Genevestigator: O75751
eggNOG: COG0477
HEGENOM: HOG000234568
Entrez Gene ID: 6581   
Pfam: PF07690   
KEGG: hsa:6581   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005329 F:dopamine transmembrane transporter activity
GO:0015651 F:quaternary ammonium group transmembrane transporter activity
GO:0019534 F:toxin transporter activity
GO:0051615 P:histamine uptake
GO:0032098 P:regulation of appetite

References (3)

[1] “Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.”  Gruendemann D.et.al.   10196521
[2] “Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.”  Verhaagh S.et.al.   9933568
[3] “Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.”  Wu X.et.al.   10966924

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW CRGPSAAALA 
61:	ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND SASATSALSC ADPLAAFPNR 
121:	SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN AWMLDLTQAI LNLGFLTGAF TLGYAADRYG 
181:	RIVIYLLSCL GVGVTGVVVA FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR 
241:	IVGIVIQMFF TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK 
301:	GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC TLILMFAWFT 
361:	SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT IERLGRRLPF AASNIVAGVA 
421:	CLVTAFLPEG IAWLRTTVAT LGRLGITMAF EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG 
481:	GIIAPFLLFR LAAVWLELPL IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS 
541:	CKCGRNKKTP VSRSHL