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2.A.1.19.25
Solute carrier family 22 member 7 (liver transporter) (Organic anion transporter 2) (hOAT2), transports the anti-viral drug, acyclovir (Dahlin et al. 2013).

Accession Number:Q9Y694
Protein Name:Solute carrier family 22 member 7
Length:548
Molecular Weight:60026.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Organic anions, Acyclovir

Cross database links:

Genevestigator: Q9Y694
eggNOG: COG0477
HEGENOM: HOG000234569
Entrez Gene ID: 10864   
Pfam: PF07690   
KEGG: hsa:10864   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015347 F:sodium-independent organic anion transmembrane transporter activity
GO:0035634 P:response to stilbenoid

References (9)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Isolation of a family of organic anion transporters from human liver and kidney.”  Sun W.et.al.   11327718
[5] “Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.”  Enomoto A.et.al.   12023506
[6] “Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.”  Kimura H.et.al.   11907186
[7] “Human organic anion transporters mediate the transport of tetracycline.”  Babu E.et.al.   11855680
[8] “Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).”  Kobayashi Y.et.al.   15901346
[9] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218

External Searches:

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Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA LPGAPANFSH 
61:	QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS RGELEDEPAT VPCSQGWEYD 
121:	HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV 
181:	STLVLGLASA ASVSYVMFAI TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW 
241:	TGGVMLLALV GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH 
301:	CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC VVVWFGVNFS 
361:	YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA GRRLTQAGTL LGTALAFGTR 
421:	LLVSSDMKSW STVLAVMGKA FSEAAFTTAY LFTSELYPTV LRQTGMGLTA LVGRLGGSLA 
481:	PLAALLDGVW LSLPKLTYGG IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE 
541:	MPMKQVQN