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2.A.1.19.29
Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1).  May be a primary polyamine uptake porter (Abdulhussein and Wallace 2013).

Accession Number:O15245
Protein Name:Solute carrier family 22 member 1
Length:554
Molecular Weight:61154.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Primary polyamines

Cross database links:

Genevestigator: O15245
eggNOG: COG0477
HEGENOM: HOG000234568
Entrez Gene ID: 6580   
Pfam: PF00083   
KEGG: hsa:6580   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005277 F:acetylcholine transmembrane transporter activity
GO:0005329 F:dopamine transmembrane transporter activity
GO:0005333 F:norepinephrine transmembrane transporter activity
GO:0015101 F:organic cation transmembrane transporter activity
GO:0015651 F:quaternary ammonium group transmembrane transporter activity
GO:0008513 F:secondary active organic cation transmembrane transporter activity
GO:0006855 P:drug transmembrane transport
GO:0048241 P:epinephrine transport
GO:0010248 P:establishment or maintenance of transmembrane electrochemical gradient

References (18)

[1] “Cloning and characterization of two human polyspecific organic cation transporters.”  Gorboulev V.et.al.   9260930
[2] “Cloning and functional expression of a human liver organic cation transporter.”  Zhang L.et.al.   9187257
[3] “Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1).”  Hayer M.et.al.   11388889
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).”  Zhang L.et.al.   9655880
[8] “Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides.”  van Montfoort J.E.et.al.   11408531
[9] “Regulation of the human organic cation transporter hOCT1.”  Ciarimboli G.et.al.   15389554
[10] “Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).”  Mueller J.et.al.   16263091
[11] “Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.”  Kimura N.et.al.   16272756
[12] “The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha.”  Saborowski M.et.al.   16436500
[13] “Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.”  Amphoux A.et.al.   16581093
[14] “The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells.”  Dias V.et.al.   17635184
[15] “Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.”  Kerb R.et.al.   12439218
[16] “Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.”  Shu Y.et.al.   12719534
[17] “Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions.”  Sakata T.et.al.   14697261
[18] “Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1).”  Itoda M.et.al.   15499200

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC QSPGVAELSQ 
61:	RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL SCVDPLASLA TNRSHLPLGP 
121:	CQDGWVYDTP GSSIVTEFNL VCADSWKLDL FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL 
181:	GTVLVNAVSG VLMAFSPNYM SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY 
241:	QMAFTVGLVA LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK 
301:	IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL MYLWFTDSVL 
361:	YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV GRIYPMAMSN LLAGAACLVM 
421:	IFISPDLHWL NIIIMCVGRM GITIAIQMIC LVNAELYPTF VRNLGVMVCS SLCDIGGIIT 
481:	PFIVFRLREV WQALPLILFA VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN 
541:	TIYLKVQTSE PSGT