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2.A.1.19.31
Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1),  Probably orthologous to 2.A.1.19.4. Functions in urate uptake from the circulation across the basolateral membrane of tubular cells (Prestin et al. 2014).

Accession Number:Q4U2R8
Protein Name:Solute carrier family 22 member 6
Length:563
Molecular Weight:61816.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Organic anions, Urate

Cross database links:

Genevestigator: Q4U2R8
eggNOG: COG0477
Entrez Gene ID: 9356   
Pfam: PF00083   
KEGG: hsa:9356   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005901 C:caveola
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0043234 C:protein complex
GO:0005452 F:inorganic anion exchanger activity
GO:0008514 F:organic anion transmembrane transporter activity
GO:0015347 F:sodium-independent organic anion transmembrane transporter activity
GO:0015742 P:alpha-ketoglutarate transport
GO:0097254 P:renal tubular secretion
GO:0031427 P:response to methotrexate
GO:0043252 P:sodium-independent organic anion transport

References (17)

[1] “Cloning of a human renal p-aminohippurate transporter, hROAT1.”  Reid G.et.al.   9762842
[2] “Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.”  Hosoyamada M.et.al.   9887087
[3] “Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.”  Lu R.et.al.   9950961
[4] “Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).”  Race J.E.et.al.   10049739
[5] “The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.”  Cihlar T.et.al.   10462545
[6] “Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.”  Bahn A.et.al.   10964714
[7] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Interaction of cysteine conjugates with human and rabbit organic anion transporter 1.”  Groves C.E.et.al.   12538807
[10] “Role of glycosylation in the organic anion transporter OAT1.”  Tanaka K.et.al.   14749323
[11] “Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1.”  Hong M.et.al.   15145940
[12] “Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).”  Srimaroeng C.et.al.   15644426
[13] “Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney.”  Tahara H.et.al.   15846473
[14] “A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.”  Perry J.L.et.al.   17038320
[15] “Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate.”  Mizuno N.et.al.   17502342
[16] “Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).”  Bleasby K.et.al.   15914676
[17] “Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)].”  Xu G.et.al.   16164626

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FASTA formatted sequence
1:	MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR PPADANLSKN 
61:	GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG ATEPCTDGWI YDNSTFPSTI 
121:	VTEWDLVCSH RALRQLAQSL YMVGVLLGAM VFGYLADRLG RRKVLILNYL QTAVSGTCAA 
181:	FAPNFPIYCA FRLLSGMALA GISLNCMTLN VEWMPIHTRA CVGTLIGYVY SLGQFLLAGV 
241:	AYAVPHWRHL QLLVSAPFFA FFIYSWFFIE SARWHSSSGR LDLTLRALQR VARINGKREE 
301:	GAKLSMEVLR ASLQKELTMG KGQASAMELL RCPTLRHLFL CLSMLWFATS FAYYGLVMDL 
361:	QGFGVSIYLI QVIFGAVDLP AKLVGFLVIN SLGRRPAQMA ALLLAGICIL LNGVIPQDQS 
421:	IVRTSLAVLG KGCLAASFNC IFLYTGELYP TMIRQTGMGM GSTMARVGSI VSPLVSMTAE 
481:	LYPSMPLFIY GAVPVAASAV TVLLPETLGQ PLPDTVQDLE SRWAPTQKEA GIYPRKGKQT 
541:	RQQQEHQKYM VPLQASAQEK NGL