TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.19.32
Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)

Accession Number:Q8IZD6
Protein Name:Solute carrier family 22 member 15
Length:547
Molecular Weight:60540.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown, NONE

Cross database links:

Genevestigator: Q8IZD6
eggNOG: COG0477
HEGENOM: HOG000234568
Entrez Gene ID: 55356   
Pfam: PF00083   
KEGG: hsa:55356   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022857 F:transmembrane transporter activity
GO:0006811 P:ion transport

References (6)

[1] “Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.”  Eraly S.A.et.al.   12372408
[2] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[3] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[6] “Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines.”  Molderings G.J.et.al.   15028572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEVEEAFQAV GEMGIYQMYL CFLLAVLLQL YVATEAILIA LVGATPSYHW DLAELLPNQS 
61:	HGNQSAGEDQ AFGDWLLTAN GSEIHKHVHF SSSFTSIASE WFLIANRSYK VSAASSFFFS 
121:	GVFVGVISFG QLSDRFGRKK VYLTGFALDI LFAIANGFSP SYEFFAVTRF LVGMMNGGMS 
181:	LVAFVLLNEC VGTAYWALAG SIGGLFFAVG IAQYALLGYF IRSWRTLAIL VNLQGTVVFL 
241:	LSLFIPESPR WLYSQGRLSE AEEALYLIAK RNRKLKCTFS LTHPANRSCR ETGSFLDLFR 
301:	YRVLLGHTLI LMFIWFVCSL VYYGLTLSAG DLGGSIYANL ALSGLIEIPS YPLCIYLINQ 
361:	KWFGRKRTLS AFLCLGGLAC LIVMFLPEKK DTGVFAVVNS HSLSLLGKLT ISAAFNIVYI 
421:	YTSELYPTVI RNVGLGTCSM FSRVGGIIAP FIPSLKYVQW SLPFIVFGAT GLTSGLLSLL 
481:	LPETLNSPLL ETFSDLQVYS YRRLGEEALS LQALDPQQCV DKESSLGSES EEEEEFYDAD 
541:	EETQMIK