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2.A.1.19.36
Organic cation transporter protein. OrcT

Accession Number:Q9VCA2
Protein Name:Organic cation transporter protein
Length:548
Molecular Weight:61003.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate organic cations

Cross database links:

eggNOG: COG0477
Entrez Gene ID: 42891   
Pfam: PF00083   
KEGG: dme:Dmel_CG6331   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022857 F:transmembrane transporter activity
GO:0006915 P:apoptotic process
GO:0006811 P:ion transport

References (5)

[1] “The Orct gene of Drosophila melanogaster codes for a putative organic cation transporter with six or 12 transmembrane domains.”  Taylor C.A.M.et.al.   9409773
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[5] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGYDDVITHL GEFGPYQKRI YYLLCLPAIV CAFHKLAGVF LLAKPDFRCA LPYENGSIYE 
61:	LSPHLWNLSY PENERCSYYD VDYTEEYLNG SIPRSSNETK TCSSYVYDRS KYLNSAVTEW 
121:	NLVCSRSLLS ATSDSLFMLG VLLGSLIFGQ MSDKLGRKPT FFASLVLQLI FGVLAAVAPE 
181:	YFSYTISRMI VGATTSGVFL VAYVIALEMV GSSYRLFAGV AMQMFFSVGF MLTAGFAYFI 
241:	HDWRWLQIAI TLPGLLFLCY YWIIPESARW LLMKGRKDEA FVIIEKAAKE NKVEVPNEIY 
301:	EQLVDEVAEK KKQDEMAASQ PAATVFDLLR YPNLRRKTLL IFFDWFVNSG VYYGLSWNTN 
361:	NLGGNQLVNF MISGAVEIPG YTLLLFTLNR WGRRSILCGT MMVAGISLLA TIFVPSDMNW 
421:	LIVACAMIGK LAITSSYGTI YIFSAEQFPT VVRNVGLGAS SMVARVGGIL APYLKLLGEI 
481:	WRPLPLIICG ALSLTAGLLS LLLPETLNKP MPETIEDGEN FGKKPAPQET AEEGGTQELS 
541:	GMLNGKSG