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2.A.1.19.8
The human organic cation transporter, SLC22A17.  The rat orthologue may be inactive (Bennett et al. 2011). It is also the cell surface receptor for Lipocalin-2 (LCN2; 24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2, followed by internalization and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2, followed by internalization and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.

Accession Number:Q8WUG5
Protein Name:The human organic cation transporter, SLC22A17 of Homo Sapiens Q8WUG5
Length:538
Molecular Weight:57686.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate organic cations

Cross database links:

NOG329488
Genevestigator: Q8WUG5 Q8WUG5 Q8WUG5
HEGENOM: HBG506863 HBG506863
Entrez Gene ID: 51310   
Pfam: PF00083   
KEGG: hsa:51310    hsa:51310   

Gene Ontology

GO:0031301 C:integral to organelle membrane
GO:0005887 C:integral to plasma membrane
GO:0005774 C:vacuolar membrane
GO:0004888 F:transmembrane receptor activity
GO:0005215 F:transporter activity
GO:0015891 P:siderophore transport
GO:0055085 P:transmembrane transport
GO:0004888 F:transmembrane signaling receptor activity
GO:0022857 F:transmembrane transporter activity

References (10)

[1] “A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells.”  Fang W.K.et.al.   17253959
[2] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake.”  Devireddy L.R.et.al.   16377569
[5] “Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R.”  Sheng Z.et.al.   19229297
[6] “A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells.”  Fang W.K.et.al.   17253959
[7] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake.”  Devireddy L.R.et.al.   16377569
[10] “Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R.”  Sheng Z.et.al.   19229297

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASDPIFTLA PPLHCHYGAF PPNASGWEQP PNASGVSVAS AALAASAASR VATSTDPSCS 
61:	GFAPPDFNHC LKDWDYNGLP VLTTNAIGQW DLVCDLGWQV ILEQILFILG FASGYLFLGY 
121:	PADRFGRRGI VLLTLGLVGP CGVGGAAAGS STGVMALRFL LGFLLAGVDL GVYLMRLELC 
181:	DPTQRLRVAL AGELVGVGGH FLFLGLALVS KDWRFLQRMI TAPCILFLFY GWPGLFLESA 
241:	RWLIVKRQIE EAQSVLRILA ERNRPHGQML GEEAQEALQD LENTCPLPAT SSFSFASLLN 
301:	YRNIWKNLLI LGFTNFIAHA IRHCYQPVGG GGSPSDFYLC SLLASGTAAL ACVFLGVTVD 
361:	RFGRRGILLL SMTLTGIASL VLLGLWDCEH PIFPTVWAQQ GNPNRDLNEA AITTFSVLGL 
421:	FSSQAAAILS TLLAAEVIPT TVRGRGLGLI MALGALGGLS GPAQRLHMGH GAFLQHVVLA 
481:	ACALLCILSI MLLPETKRKL LPEVLRDGEL CRRPSLLRQP PPTRCDHVPL LATPNPAL