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2.A.1.2.10
Quinolone (and other drug):H+ antiporter, NorA.  Many synthetic inhibitors have been identified (Bhaskar et al. 2016).

Accession Number:P0A0J7
Protein Name:Quinolone resistance protein NorA aka SAV0695 aka SA0650 aka MW0657
Length:388
Molecular Weight:42265.00
Species:Staphylococcus aureus [1280]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Quinolones, H+

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015520 F:tetracycline:hydrogen antiporter activity
GO:0046677 P:response to antibiotic
GO:0015904 P:tetracycline transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.”  Yoshida H.et.al.   2174864
[2] “A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus.”  Ohshita Y.et.al.   2173911

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKQIFVLYF NIFLIFLGIG LVIPVLPVYL KDLGLTGSDL GLLVAAFALS QMIISPFGGT 
61:	LADKLGKKLI ICIGLILFSV SEFMFAVGHN FSVLMLSRVI GGMSAGMVMP GVTGLIADIS 
121:	PSHQKAKNFG YMSAIINSGF ILGPGIGGFM AEVSHRMPFY FAGALGILAF IMSIVLIHDP 
181:	KKSTTSGFQK LEPQLLTKIN WKVFITPVIL TLVLSFGLSA FETLYSLYTA DKVNYSPKDI 
241:	SIAITGGGIF GALFQIYFFD KFMKYFSELT FIAWSLLYSV VVLILLVFAN GYWSIMLISF 
301:	VVFIGFDMIR PAITNYFSNI AGERQGFAGG LNSTFTSMGN FIGPLIAGAL FDVHIEAPIY 
361:	MAIGVSLAGV VIVLIEKQHR AKLKEQNM