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2.A.1.2.11
Monoamine transporter; drug (doxorubicin, ethidium bromide-6-G):H+ antiporter

Accession Number:Q01818
Protein Name:VMT1 aka VMAT1 aka SLC18A1 aka CGAT
Length:521
Molecular Weight:55935.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate Monoamines, doxorubicin, Ethidium bromide-6-G, H+

Cross database links:

Genevestigator: Q01818
eggNOG: roNOG06781
RefSeq: NP_037284.2   
Entrez Gene ID: 25693   
Pfam: PF07690   
KEGG: rno:25693   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0016021 C:integral to membrane
GO:0015238 F:drug transmembrane transporter activity
GO:0015893 P:drug transport
GO:0006836 P:neurotransmitter transport
GO:0055085 P:transmembrane transport

References (1)

[1] “A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter.”  Liu Y.et.al.   1505023

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MLQVVLGAPQ RLLKEGRQSR KLVLVVVFVA LLLDNMLLTV VVPIVPTFLY ATEFKDSNSS 
61:	LHRGPSVSSQ QALTSPAFST IFSFFDNTTT TVEEHVPFRV TWTNGTIPPP VTEASSVPKN 
121:	NCLQGIEFLE EENVRIGILF ASKALMQLLV NPFVGPLTNR IGYHIPMFVG FMIMFLSTLM 
181:	FAFSGTYALL FVARTLQGIG SSFSSVAGLG MLASVYTDNY ERGRAMGIAL GGLALGLLVG 
241:	APFGSVMYEF VGKSSPFLIL AFLALLDGAL QLCILWPSKV SPESAMGTSL LTLLKDPYIL 
301:	VAAGSICLAN MGVAILEPTL PIWMMQTMCS PEWQLGLAFL PASVAYLIGT NLFGVLANKM 
361:	GRWLCSLVGM VAVGISLLCV PLAHNIFGLI GPNAGLGFAI GMVDSSLMPI MGYLVDLRHT 
421:	SVYGSVYAIA DVAFCVGFAI GPSTGGVIVQ VIGFPWLMVI IGTINIIYAP LCCFLQNPPA 
481:	KEEKRAILSQ ECPTETQMYT FQKPTKAFPL GENSDDPSSG E