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2.A.1.2.115
Multidrug resistance MDR exporter of 583 aas and 12 TMSs. It is involved in resistance to the antifungal drugs miconazole, tioconazole, clotrimazole and ketoconazole as well as to quinidine   (Costa et al. 2013; Costa et al. 2016).  It also plays a role in biofilm formation. Compared to the wild type, the C. glabrata ∆qdr2 mutant showed lower adhesion activity and higher fluconazole susceptibility when assessed as a biofilm. The mutant also showed decreased metabolic activity during biofilm formation and grew more slowly under neutral-basic pH conditions. The qdr2 deletion in C. glabrata resulted in an impaired ability to maintain pH homeostasis, which led in turn to a reduction of cell growth and of adherence to an artificial matrix (Widiasih Widiyanto et al. 2019).

Accession Number:Q6FSQ7
Protein Name:Multidrug transporter QDR2
Length:583
Molecular Weight:64364.00
Species:Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) [284593]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MMEDQQSLHS FISDYDQRSH AVEKYDGPDL SEVDSEDNDK MIKTNEDEAV KEPIYRTRSN 
61:	QTEPDIANAP PYSRFDAKYK MALVLQCAYT GLFSTMAGAI YYPVLSVIEK QFHITEELVN 
121:	ITVVVYFIFQ GIAPTLMGGL ADSLGRRPVV LFAVTVYFGA CIGLACAQTY AQIVVLRCLQ 
181:	AAGISPVIAI NSGIIGDVTT RAERGGYVGY ISGFQVLGSA FGALIGAGLS SRWGWRSIFW 
241:	FLAIGSGVCL VFSIIMLPET KRTIVGNGSV TPRNYLNRAP LLMFPLIRRK LHLDDPEYET 
301:	LEPRTQLSLL APLSILKVKE ISILLVTAGI QFATWSTHQT ALSTVLSKNY HLSVAKIGLC 
361:	YLPTGICTLI SIVTSGRYLN WSYRRRFAKH KVWLKEQEEI LVKENGYSRE EVQNIINNDP 
421:	KYVFNLVQTR LHAAFVTLLL SSSGFVAFGW CIDVKAPLAS VLVMSGFASL FSNCILTFST 
481:	TLIVDIFPSK TSTATGCLNL FRCLLSALFI GCLSKMATSM TYGGVFTFLG ALTALSACPL 
541:	FYLLKNGREI TLKRKRKEDA SRAFALSVAN EKAEAEGKAE ESR