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2.A.1.2.12
Chromaffin granule monoamine (and drug) transporter, VAT1

Accession Number:P54219
Protein Name:VMT1 aka VAT1 aka SLC18A1 aka VMAT1
Length:525
Molecular Weight:56257.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate Monoamines, drugs

Cross database links:

Genevestigator: P54219 P54219
eggNOG: prNOG09122 NOG255549
HEGENOM: HBG714968 HOG000018545
RefSeq: NP_001129163.1    NP_001135796.1    NP_001135797.1    NP_003044.1   
Entrez Gene ID: 6570   
Pfam: PF07690   
OMIM: 193002  gene
KEGG: hsa:6570    hsa:6570   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0015238 F:drug transmembrane transporter activity
GO:0008504 F:monoamine transmembrane transporter activity
GO:0015893 P:drug transport
GO:0015844 P:monoamine transport
GO:0006836 P:neurotransmitter transport
GO:0055085 P:transmembrane transport
GO:0070083 C:clathrin sculpted monoamine transport vesicle membrane
GO:0015222 F:serotonin transmembrane transporter activity
GO:0071285 P:cellular response to lithium ion
GO:0006855 P:drug transmembrane transport
GO:0051612 P:negative regulation of serotonin uptake
GO:0033603 P:positive regulation of dopamine secretion
GO:0051610 P:serotonin uptake

References (2)

[1] “Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.”  Erickson J.D.et.al.   8643547
[2] “Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.”  Erickson J.D.et.al.   8643547

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLRTILDAPQ RLLKEGRASR QLVLVVVFVA LLLDNMLFTV VVPIVPTFLY DMEFKEVNSS 
61:	LHLGHAGSSP HALASPAFST IFSFFNNNTV AVEESVPSGI AWMNDTASTI PPPATEAISA 
121:	HKNNCLQGTG FLEEEITRVG VLFASKAVMQ LLVNPFVGPL TNRIGYHIPM FAGFVIMFLS 
181:	TVMFAFSGTY TLLFVARTLQ GIGSSFSSVA GLGMLASVYT DDHERGRAMG TALGGLALGL 
241:	LVGAPFGSVM YEFVGKSAPF LILAFLALLD GALQLCILQP SKVSPESAKG TPLFMLLKDP 
301:	YILVAAGSIC FANMGVAILE PTLPIWMMQT MCSPKWQLGL AFLPASVSYL IGTNLFGVLA 
361:	NKMGRWLCSL IGMLVVGTSL LCVPLAHNIF GLIGPNAGLG LAIGMVDSSM MPIMGHLVDL 
421:	RHTSVYGSVY AIADVAFCMG FAIGPSTGGA IVKAIGFPWL MVITGVINIV YAPLCYYLRS 
481:	PPAKEEKLAI LSQDCPMETR MYATQKPTKE FPLGEDSDEE PDHEE