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2.A.1.2.13
Vesicular acetylcholine:H+ antiporter, UNC-17/VAChT.  Mutants grow slowly and are uncoordinated, but the defect can be corrected by mutation of an interacting monotopic protein, SUP-1 (Mathews et al. 2012). 

Accession Number:P34711
Protein Name:UN17 aka Unc17 aka UNC-17 aka ZC416.8
Length:532
Molecular Weight:58643.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Acetylcholine

Cross database links:

RefSeq: NP_001023602.1   
Entrez Gene ID: 177124   
Pfam: PF07690   
KEGG: cel:ZC416.8   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005277 F:acetylcholine transmembrane transporter act...
GO:0015238 F:drug transmembrane transporter activity
GO:0015870 P:acetylcholine transport
GO:0015893 P:drug transport
GO:0006937 P:regulation of muscle contraction
GO:0055085 P:transmembrane transport

References (3)

[1] “The Caenorhabditis elegans unc-17 gene: a putative vesicular acetylcholine transporter.”  Alfonso A.et.al.   8342028
[2] “Alternative splicing leads to two cholinergic proteins in Caenorhabditis elegans.”  Alfonso A.et.al.   8057385
[3] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGFNVPVINR DSEILKADAK KWLEQQDNQK KCVLVIVSIA LLLDNMLYMV IVPIIPKYLR 
61:	DIHNYQVTFE GYHNETSQLA NGTYLVREVG GRINFLDEEL ELGWLFASKA LLQIFVNPFS 
121:	GYIIDRVGYE IPMILGLCTM FFSTAIFALG KSYGVLLFAR SLQGFGSAFA DTSGLAMIAD 
181:	RFTEENERSA ALGIALAFIS FGCLVAPPFG SVLYSLAGKP VPFLILSFVC LADAIAVFMV 
241:	INPHRRGTDS HGEKVQGTPM WRLFMDPFIA CCSGALIMAN VSLAFLEPTI TTWMSEMMPD 
301:	TPGWLVGVIW LPPFFPHVLG VYVTVKMLRA FPHHTWAIAM VGLAMEGIAC FAIPYTTSVM 
361:	QLVIPLSFVC FGIALIDTSL LPMLGHLVDT RHVSVYGSVY AIADISYSLA YAFGPIIAGW 
421:	IVTNWGFTAL NIIIFATNVT YAPVLFLLRK VHSYDTLGAK GDTAEMTQLN SSAPAGGYNG 
481:	KPEATTAESY QGWEDQQSYQ NQAQIPNHAV SFQDSRPQAE FPAGYDPLNP QW